Pulmobi
Generic Name
Pulmonexin 801 mg
Manufacturer
BioGenesis Pharma Ltd.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pulmobi 801 mg tablet | ৳ 125.00 | ৳ 1,250.00 |
Description
Overview of the medicine
Pulmobi 801 mg tablet is a novel medication primarily indicated for the management of chronic obstructive pulmonary disease (COPD) and severe asthma. It combines potent bronchodilatory effects with significant anti-inflammatory actions to improve lung function and reduce exacerbations.
Uses & Indications
Dosage
Adults
One 801 mg tablet once daily.
Elderly
No dose adjustment typically required, but monitor for adverse effects.
Renal_impairment
Mild to moderate impairment: No adjustment. Severe impairment: Use with caution, consider dose reduction.
How to Take
Take orally with water, preferably at the same time each day. Can be taken with or without food.
Mechanism of Action
Pulmobi 801 mg works by selectively activating beta-2 adrenergic receptors in the bronchial smooth muscle, leading to bronchodilation. Additionally, it inhibits the release of pro-inflammatory mediators and downregulates inflammatory pathways, thereby reducing airway inflammation and hyperresponsiveness.
Pharmacokinetics
Onset
Onset of bronchodilation within 30 minutes.
Excretion
Mainly excreted renally (60%) with some fecal excretion (40%).
Half life
Approximately 12-18 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via CYP3A4 and glucuronidation pathways.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- Acute asthma attacks or status asthmaticus
- Severe uncontrolled cardiac conditions
Drug Interactions
Diuretics
May increase the risk of hypokalemia.
Beta-blockers
May reduce the bronchodilatory effect and increase the risk of bronchospasm.
MAOIs/Tricyclic Antidepressants
May potentiate the cardiovascular effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include tachycardia, tremors, palpitations, headache, and hypokalemia. Treatment is supportive and symptomatic; consider beta-blockers for severe cardiac effects.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation; weigh benefits vs. risks.
Side Effects
Contraindications
- Hypersensitivity to the active substance or any excipients
- Acute asthma attacks or status asthmaticus
- Severe uncontrolled cardiac conditions
Drug Interactions
Diuretics
May increase the risk of hypokalemia.
Beta-blockers
May reduce the bronchodilatory effect and increase the risk of bronchospasm.
MAOIs/Tricyclic Antidepressants
May potentiate the cardiovascular effects.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include tachycardia, tremors, palpitations, headache, and hypokalemia. Treatment is supportive and symptomatic; consider beta-blockers for severe cardiac effects.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation; weigh benefits vs. risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Patented
Clinical Trials
Phase III trials demonstrated significant improvement in FEV1 and reduction in COPD exacerbations compared to placebo. Ongoing long-term safety studies.
Lab Monitoring
- Serum potassium levels (especially with diuretics)
- Lung function tests (FEV1)
- ECG (in patients with cardiac risk factors)
Doctor Notes
- Educate patients on proper use and the distinction between maintenance and rescue therapy.
- Monitor patients for potential cardiovascular and electrolyte disturbances.
- Consider bone density assessment in high-risk patients on long-term therapy.
Patient Guidelines
- Do not exceed the prescribed dose.
- Do not stop the medication suddenly without consulting your doctor.
- Report any worsening of respiratory symptoms immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or tremor; if affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking and exposure to respiratory irritants.
- Regular exercise (as tolerated).
- Maintain a healthy diet.
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