Pylotrip-R
Generic Name
Rabeprazole Sodium
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pylotrip r 20 mg tablet | ৳ 55.00 | N/A |
Description
Overview of the medicine
Pylotrip-R 20 mg Tablet contains Rabeprazole, a proton pump inhibitor, used to reduce the amount of acid produced in the stomach. It treats conditions like heartburn, acid reflux, stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily in combination with antibiotics for 7-14 days. Zollinger-Ellison: Initial 60 mg once daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution with severe hepatic impairment.
Renal_impairment
No dose adjustment required for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Pylotrip-R should be swallowed whole with water before a meal (preferably in the morning). Do not chew or crush the tablet.
Mechanism of Action
Rabeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells. This action effectively reduces basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted via the kidneys (about 90%) as metabolites, with a small amount excreted in feces.
Half life
Approximately 1-2 hours
Absorption
Rapidly absorbed after oral administration, bioavailability is about 52% (first pass metabolism). Peak plasma concentrations (Cmax) are reached within 2-5 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 (CYP3A4 and CYP2C19) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole or any components of the formulation.
- Hypersensitivity to other benzimidazole substituted proton pump inhibitors.
Drug Interactions
Digoxin
Increased digoxin exposure due to increased gastric pH.
Warfarin
Increased INR and prothrombin time reported, monitor closely.
Methotrexate
Increased and prolonged methotrexate serum levels and/or its metabolite.
Atazanavir/Nelfinavir
Coadministration with PPIs may significantly reduce plasma concentrations of atazanavir/nelfinavir, leading to loss of antiviral effect.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include confusion, blurred vision, tachycardia, nausea, sweating, headache, and dry mouth. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if rabeprazole is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole or any components of the formulation.
- Hypersensitivity to other benzimidazole substituted proton pump inhibitors.
Drug Interactions
Digoxin
Increased digoxin exposure due to increased gastric pH.
Warfarin
Increased INR and prothrombin time reported, monitor closely.
Methotrexate
Increased and prolonged methotrexate serum levels and/or its metabolite.
Atazanavir/Nelfinavir
Coadministration with PPIs may significantly reduce plasma concentrations of atazanavir/nelfinavir, leading to loss of antiviral effect.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include confusion, blurred vision, tachycardia, nausea, sweating, headache, and dry mouth. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if rabeprazole is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Rabeprazole in various acid-related disorders. Studies support its use for GERD, ulcers, and H. pylori eradication.
Lab Monitoring
- Monitor INR/prothrombin time in patients on warfarin.
- Consider serum magnesium levels with prolonged use (>3 months).
Doctor Notes
- Consider differential diagnosis for persistent dyspepsia despite PPI therapy.
- Monitor for bone density and magnesium levels in long-term use.
- Ensure H. pylori eradication therapy is completed as prescribed.
Patient Guidelines
- Take Pylotrip-R before your first meal of the day.
- Swallow the tablet whole; do not chew, crush, or break it.
- Do not stop taking the medicine without consulting your doctor, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger acid reflux (e.g., fatty foods, caffeine, alcohol, spicy foods).
- Elevate the head of your bed.
- Eat smaller, more frequent meals.
- Maintain a healthy weight.
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Global Brand Names
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