Pyridox
Generic Name
Pyridoxine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pyridox 20 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Pyridoxine Hydrochloride is Vitamin B6, essential for various metabolic functions, including protein, fat, and carbohydrate metabolism. It plays a crucial role in nerve function, red blood cell formation, and immune system health.
Uses & Indications
Dosage
Adults
Typical oral dose for deficiency: 10-20 mg daily for 3 weeks, then 2-5 mg daily as maintenance. For drug-induced deficiency: 10-50 mg daily. For peripheral neuropathy due to isoniazid: 10 mg daily.
Elderly
No specific dosage adjustment required, but may be more susceptible to adverse effects with high doses.
Renal_impairment
No specific dosage adjustment recommended for mild to moderate impairment. Use with caution in severe renal impairment.
How to Take
Administer orally, with or without food.
Mechanism of Action
Pyridoxine is converted in the body to its active coenzyme form, pyridoxal 5'-phosphate (PLP), which is involved in over 100 enzyme reactions, primarily in amino acid metabolism, but also in carbohydrate and lipid metabolism. It is crucial for neurotransmitter synthesis and heme synthesis.
Pharmacokinetics
Onset
Therapeutic effects may take days to weeks to manifest, depending on the severity of deficiency.
Excretion
Excreted primarily in the urine as 4-pyridoxic acid (the major inactive metabolite).
Half life
Approximately 15-20 days (for PLP), short for unphosphorylated pyridoxine (2-3 hours).
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the jejunum. Peak plasma concentrations are achieved within 1.5-2 hours.
Metabolism
Metabolized in the liver to pyridoxal 5'-phosphate (PLP) and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation
Drug Interactions
Levodopa
High doses of pyridoxine can decrease the effectiveness of levodopa (this interaction is usually avoided with co-administration of carbidopa).
Isoniazid
Increases pyridoxine excretion and can cause deficiency.
Penicillamine
Increases pyridoxine excretion.
Oral Contraceptives
May increase pyridoxine requirements.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (usually with very high doses, >200 mg/day for prolonged periods) may include severe sensory neuropathy, ataxia, and skin lesions. Treatment is symptomatic and supportive. Discontinue the drug.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation within recommended daily allowances. Higher doses may be used for nausea and vomiting in pregnancy under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to pyridoxine or any component of the formulation
Drug Interactions
Levodopa
High doses of pyridoxine can decrease the effectiveness of levodopa (this interaction is usually avoided with co-administration of carbidopa).
Isoniazid
Increases pyridoxine excretion and can cause deficiency.
Penicillamine
Increases pyridoxine excretion.
Oral Contraceptives
May increase pyridoxine requirements.
Storage
Store in a cool, dry place, below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (usually with very high doses, >200 mg/day for prolonged periods) may include severe sensory neuropathy, ataxia, and skin lesions. Treatment is symptomatic and supportive. Discontinue the drug.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation within recommended daily allowances. Higher doses may be used for nausea and vomiting in pregnancy under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, drug stores, supermarkets
Approval Status
Approved
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical experience and studies have established the efficacy and safety of pyridoxine for deficiency conditions and specific indications. Ongoing research may explore new roles or optimal dosing strategies.
Lab Monitoring
- Pyridoxine levels (in severe deficiency or toxicity concerns)
- Liver function tests (with very high doses)
Doctor Notes
- Emphasize patient education on avoiding excessive self-dosing.
- Consider underlying causes of deficiency before initiating therapy.
- Monitor for neurological symptoms with high-dose, long-term use.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Pyridoxine is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in B vitamins.
- Avoid excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.