quilev
Generic Name
Levofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| quilev 500 mg tablet | ৳ 15.00 | N/A |
Description
Overview of the medicine
Quilev 500 mg Tablet is an antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and prostate infections. It belongs to the fluoroquinolone class of antibiotics.
Uses & Indications
Dosage
Adults
Generally 500 mg orally once daily for 7-14 days, depending on the infection.
Elderly
No specific dose adjustment is generally required, but dose reduction may be necessary in patients with impaired renal function.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For CrCl 20-49 mL/min, initial dose 500 mg, then 250 mg every 24 hours.
How to Take
Take orally with or without food. Ensure adequate hydration. Do not take with antacids containing magnesium or aluminum, sucralfate, didanosine (chewable/buffered tablets or pediatric powder), or metal cations (e.g., iron, zinc).
Mechanism of Action
Levofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Rapid.
Excretion
Primarily excreted unchanged in the urine, mainly by glomerular filtration and tubular secretion.
Half life
6-8 hours.
Absorption
Rapid and almost complete absorption after oral administration.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to levofloxacin or other fluoroquinolones.
- History of quinolone-associated tendinitis or tendon rupture.
- Epilepsy or other seizure disorders.
- Children and growing adolescents.
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures when co-administered with fluoroquinolones.
Warfarin
May enhance the anticoagulant effects of warfarin, increasing the risk of bleeding. Monitor INR closely.
Corticosteroids
Increased risk of tendinitis and tendon rupture when co-administered with fluoroquinolones.
Antacids, Sucralfate, Metal Cations
Can significantly reduce oral bioavailability of levofloxacin. Administer levofloxacin at least 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, protected from light and moisture.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage may be considered. Monitor ECG for QT prolongation.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless the potential benefits outweigh the risks. Animal studies indicate potential harm to fetal cartilage. Levofloxacin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of levofloxacin for various approved indications. Post-marketing surveillance continues to monitor its safety profile.
Lab Monitoring
- Renal function tests (creatinine clearance, serum creatinine) in patients with impaired renal function.
- Liver function tests (ALT, AST) if prolonged treatment or liver impairment is suspected.
- Blood glucose levels in diabetic patients due to potential dysglycemia.
Doctor Notes
- Assess renal function and potential drug interactions before initiating therapy.
- Monitor patients for signs of tendinopathy, peripheral neuropathy, and CNS effects.
- Educate patients on potential adverse effects, especially black box warnings, and when to seek immediate medical attention.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better.
- Avoid excessive exposure to direct sunlight or artificial UV light (e.g., tanning beds) and use sunscreen.
- Report any new or worsening muscle pain, weakness, numbness, tingling, or changes in sensation immediately.
- Do not take antacids, sucralfate, didanosine, or products containing iron/zinc at the same time as levofloxacin.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Driving Precautions
Levofloxacin may cause dizziness, lightheadedness, or visual disturbances. Patients should assess their reaction to the drug before driving or operating machinery.
Lifestyle Advice
- Stay well-hydrated throughout the treatment period.
- Avoid alcohol consumption during treatment as it may exacerbate side effects.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.