Qutap
Generic Name
Quetiapine Fumarate
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| qutap 100 mg tablet | ৳ 10.00 | ৳ 60.00 |
Description
Overview of the medicine
Qutap 100 mg Tablet contains Quetiapine Fumarate, an atypical antipsychotic medication used for the treatment of schizophrenia, bipolar disorder (manic, depressive, and maintenance episodes), and as an adjunctive treatment for major depressive disorder.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 25-50 mg twice daily, titrated to 300-450 mg/day in 2-3 divided doses. Max 750 mg/day. Bipolar Mania: Initially 100 mg on Day 1, 200 mg on Day 2, then titrate to 400-800 mg/day. Bipolar Depression: 50 mg at bedtime, titrate to 300 mg at bedtime.
Elderly
Initiate with 25 mg/day, increasing by 25-50 mg/day depending on clinical response and tolerability. Slower titration is recommended.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. For severe impairment, initiate with 25 mg/day and titrate slowly.
How to Take
Qutap tablet should be taken orally, with or without food. It should be swallowed whole and not crushed or chewed.
Mechanism of Action
Quetiapine's therapeutic effects are mediated through a combination of antagonism at serotonin (5-HT2A) and dopamine (D1 and D2) receptors. It also has affinity for histamine H1 and adrenergic α1/α2 receptors, contributing to its sedative and orthostatic hypotensive effects.
Pharmacokinetics
Onset
Sedative effects may begin within hours. Antipsychotic effects typically take several weeks to fully manifest.
Excretion
Approximately 73% excreted in the urine and 20% in the feces within 5 days, mainly as metabolites.
Half life
Approximately 6-7 hours for quetiapine; the active metabolite norquetiapine has a half-life of about 12 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring approximately 1.5 hours after oral administration.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 3A4 (CYP3A4) enzyme system, to active (norquetiapine) and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to quetiapine or any component of the tablet.
- Concomitant use with strong cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, erythromycin, protease inhibitors).
Drug Interactions
CNS Depressants
Additive effects with alcohol and other CNS depressants. Avoid concomitant use.
CYP3A4 Inducers
May decrease quetiapine plasma concentrations (e.g., phenytoin, carbamazepine, rifampicin). Dose increase of quetiapine may be necessary.
Antihypertensives
May enhance orthostatic hypotension effects.
CYP3A4 Inhibitors
May increase quetiapine plasma concentrations (e.g., ketoconazole, erythromycin). Dose reduction of quetiapine may be necessary.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Management is primarily supportive, involving maintaining an open airway, ensuring adequate oxygenation and ventilation, and monitoring cardiovascular function. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in human milk; avoid breastfeeding during treatment.
Side Effects
Contraindications
- Hypersensitivity to quetiapine or any component of the tablet.
- Concomitant use with strong cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, erythromycin, protease inhibitors).
Drug Interactions
CNS Depressants
Additive effects with alcohol and other CNS depressants. Avoid concomitant use.
CYP3A4 Inducers
May decrease quetiapine plasma concentrations (e.g., phenytoin, carbamazepine, rifampicin). Dose increase of quetiapine may be necessary.
Antihypertensives
May enhance orthostatic hypotension effects.
CYP3A4 Inhibitors
May increase quetiapine plasma concentrations (e.g., ketoconazole, erythromycin). Dose reduction of quetiapine may be necessary.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Management is primarily supportive, involving maintaining an open airway, ensuring adequate oxygenation and ventilation, and monitoring cardiovascular function. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in human milk; avoid breastfeeding during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific expiry date mentioned on the packaging.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent, generic available
WHO Essential Medicine
YesClinical Trials
Quetiapine has undergone extensive clinical trials demonstrating its efficacy and safety in various psychiatric conditions. Ongoing research continues to explore its full therapeutic potential and optimize treatment strategies.
Lab Monitoring
- Fasting plasma glucose (baseline, 4-12 weeks after initiation, then annually)
- Lipid profile (cholesterol, triglycerides) (baseline, 4-12 weeks after initiation, then annually)
- Weight/BMI (baseline, frequently during initial treatment, then regularly)
- Blood pressure (baseline, frequently during initial treatment, then regularly)
- Complete blood count (CBC) with differential (if signs of infection or decreased WBC occur)
- Thyroid Function Tests (TSH) (baseline and periodically)
Doctor Notes
- Prior to initiating Qutap, conduct a thorough medical history, including cardiac risk factors and metabolic assessments.
- Monitor patients for metabolic changes (glucose, lipids, weight) and blood pressure regularly.
- Advise patients about the risk of orthostatic hypotension, sedation, and the importance of not stopping medication abruptly.
Patient Guidelines
- Take Qutap exactly as prescribed by your doctor.
- Do not stop taking the medication abruptly, as this can lead to withdrawal symptoms or relapse.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for the next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Qutap may cause drowsiness, dizziness, and impaired judgment. Do not drive or operate heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking Qutap, as it can intensify drowsiness.
- Stand up slowly from a sitting or lying position to minimize dizziness or lightheadedness due to orthostatic hypotension.
- Monitor your weight and blood sugar regularly, as quetiapine can cause weight gain and affect blood glucose levels.
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