r-saline-n
Generic Name
r-saline-n-1025-gm-powder
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| r saline n 1025 gm powder | ৳ 4.50 | N/A |
Description
Overview of the medicine
R-Saline-N 1025 gm powder is an oral rehydration salt formulation used to prevent and treat dehydration due to acute diarrhea and other conditions. It contains a balanced mixture of electrolytes and glucose to replenish lost fluids and salts in the body, following the standard WHO ORS formulation.
Uses & Indications
Dosage
Adults
For mild to moderate dehydration: 50-100 mL per kg body weight over 4-6 hours. For maintenance: As per thirst, usually 1 liter after each loose stool. For the 1025 gm powder, reconstitute as directed on the label to make the required volume of solution. A standard 20.5g sachet is typically dissolved in 1 liter of clean water.
Elderly
Same as adults, with careful monitoring for fluid overload in those with cardiac or renal impairment. May require slower administration.
Renal_impairment
Use with caution; electrolyte balance, especially potassium, should be monitored closely to avoid hyperkalemia. Not for use in severe renal failure.
How to Take
The powder must be dissolved completely in the recommended volume of clean drinking water (boiled and cooled water is best) before consumption. Do not mix with milk, soup, or fruit juice, as this can alter the osmolality and effectiveness. Do not add extra sugar. Sip slowly.
Mechanism of Action
Works by utilizing the sodium-glucose co-transport system in the small intestine, where glucose facilitates the absorption of sodium and water. This helps to rehydrate the body and restore electrolyte balance efficiently.
Pharmacokinetics
Onset
Rapid, typically within 30 minutes to 1 hour of administration, with symptomatic improvement.
Excretion
Excess water and electrolytes are excreted primarily via kidneys, adjusted to maintain body fluid and electrolyte balance.
Half life
Not applicable for a mixture of salts and glucose; components are utilized/excreted continuously based on physiological needs.
Absorption
Electrolytes (sodium, potassium, chloride, citrate) and glucose are readily absorbed from the gastrointestinal tract through specific transport mechanisms.
Metabolism
Glucose is metabolized for energy; electrolytes are not metabolized but participate in physiological processes and are maintained at homeostatic levels.
Side Effects
Contraindications
- Severe dehydration requiring immediate intravenous fluids
- Anuria (absence of urine formation)
- Intestinal obstruction (ileus)
- Severe vomiting preventing oral intake
- Glucose malabsorption syndrome
Drug Interactions
N/A
No significant drug interactions are generally reported with ORS when used appropriately, as its components are essential physiological substances.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep the container tightly closed. Keep out of reach of children.
Overdose
Overdose is rare with proper reconstitution and administration. However, excessive intake of highly concentrated solution or in patients with impaired renal function may lead to hypernatremia or hyperkalemia. Treatment involves prompt discontinuation, correction of electrolyte imbalance, and fluid management under medical supervision.
Pregnancy & Lactation
R-Saline-N is considered safe for use during pregnancy and lactation as it helps to restore essential fluid and electrolyte balance, which is crucial for maternal and fetal/infant health.
Side Effects
Contraindications
- Severe dehydration requiring immediate intravenous fluids
- Anuria (absence of urine formation)
- Intestinal obstruction (ileus)
- Severe vomiting preventing oral intake
- Glucose malabsorption syndrome
Drug Interactions
N/A
No significant drug interactions are generally reported with ORS when used appropriately, as its components are essential physiological substances.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep the container tightly closed. Keep out of reach of children.
Overdose
Overdose is rare with proper reconstitution and administration. However, excessive intake of highly concentrated solution or in patients with impaired renal function may lead to hypernatremia or hyperkalemia. Treatment involves prompt discontinuation, correction of electrolyte imbalance, and fluid management under medical supervision.
Pregnancy & Lactation
R-Saline-N is considered safe for use during pregnancy and lactation as it helps to restore essential fluid and electrolyte balance, which is crucial for maternal and fetal/infant health.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened powder when stored correctly. Reconstituted solution should be consumed within 24 hours.
Availability
Pharmacies, hospitals, community health centers
Approval Status
Approved by DGDA (Directorate General of Drug Administration)
Patent Status
Generic (Patent Expired)
WHO Essential Medicine
YesClinical Trials
The basic WHO-recommended ORS formulation, which R-Saline-N follows, has been extensively studied and proven effective through numerous clinical trials worldwide since its development. It is a cornerstone of global public health interventions for diarrheal disease.
Lab Monitoring
- Serum electrolytes (especially sodium and potassium, in severe cases or with comorbidities like renal or cardiac disease)
- Renal function tests (if renal impairment is suspected or pre-existing)
Doctor Notes
- Emphasize proper reconstitution with the correct water volume to avoid hyperosmolarity.
- Advise patients on continuous feeding, especially breastfeeding, for children during diarrhea.
- Educate on critical hygiene practices (handwashing, safe water) to prevent re-infection and transmission.
Patient Guidelines
- Always use clean, boiled, and cooled water for reconstitution. Follow instructions for the exact volume.
- Do not store reconstituted solution for more than 24 hours at room temperature; discard any unused portion.
- Continue normal feeding for children, including breastfeeding, during diarrhea, alongside ORS administration.
Missed Dose Advice
As R-Saline-N is typically taken as needed after each loose stool or vomiting episode, there isn't a 'missed dose' in the traditional sense. Simply continue administering the solution as per the hydration needs of the patient.
Driving Precautions
None; R-Saline-N does not impair mental alertness or physical coordination, so it does not affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene (handwashing, safe water, safe food preparation) to prevent recurrence of diarrheal diseases.
- Ensure access to clean drinking water.
- Encourage healthy eating habits.
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