Rabenta
Generic Name
Rabeprazole
Manufacturer
ACME Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rabenta 20 mg tablet | ৳ 7.00 | ৳ 70.00 |
| rabenta 20 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Rabenta (Rabeprazole) is a proton pump inhibitor (PPI) used to treat conditions caused by excess stomach acid, such as heartburn, gastroesophageal reflux disease (GERD), and peptic ulcers.
Uses & Indications
Dosage
Adults
Typically 20 mg once daily, usually in the morning before breakfast. May be increased to 40 mg daily for severe conditions or up to 60 mg twice daily for Zollinger-Ellison Syndrome.
Elderly
No dosage adjustment generally required, but caution is advised.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment. Caution with severe impairment.
How to Take
Take orally, swallowed whole with water. Do not chew or crush. Best taken before breakfast.
Mechanism of Action
Rabeprazole inhibits the H+/K+-ATPase enzyme system (the 'proton pump') at the secretory surface of the gastric parietal cell, thereby blocking the final step of acid production.
Pharmacokinetics
Onset
Within 1 hour; maximal effect within 2-4 hours.
Excretion
Primarily excreted in urine (approximately 90%) and feces (approximately 10%).
Half life
Approximately 1-2 hours.
Absorption
Rapidly absorbed after oral administration; bioavailability is about 52% and increases with repeated dosing.
Metabolism
Extensively metabolized in the liver via cytochrome P450 (CYP2C19 and CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole or any proton pump inhibitor
- Known allergic reaction to the drug components
Drug Interactions
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Potential reduction in antiplatelet effect (less significant than with omeprazole).
Methotrexate
Increased plasma concentration of methotrexate.
Ketoconazole, Itraconazole
Reduced absorption due to altered gastric pH.
Storage
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include confusion, headache, drowsiness, blurred vision, fast heartbeat, nausea, vomiting, sweating, and dry mouth. Management is symptomatic and supportive; hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Avoid during breastfeeding as rabeprazole is excreted in milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (varies by manufacturer)
Availability
Available in pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have established rabeprazole's efficacy and safety for acid-related disorders.
Lab Monitoring
- Monitor INR in patients on warfarin
- Monitor magnesium levels with prolonged use (especially with diuretics)
Doctor Notes
- Consider potential drug interactions, especially with narrow therapeutic index drugs.
- Advise patients on lifestyle modifications alongside medication.
Patient Guidelines
- Take medicine exactly as prescribed
- Do not stop taking without consulting your doctor
- Inform your doctor about all other medications you are taking
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty, acidic)
- Eat smaller, more frequent meals
- Avoid lying down immediately after eating
- Elevate head of bed for GERD symptoms
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.