Rabistar
Generic Name
Rabeprazole Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rabistar 20 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Rabeprazole is a proton pump inhibitor (PPI) used to treat conditions involving excessive stomach acid production, such as gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Typically 20 mg once daily, taken before a meal. Duration of treatment varies depending on the condition.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Take the tablet whole with a glass of water, preferably in the morning before breakfast. Do not chew, crush, or break the tablet.
Mechanism of Action
Rabeprazole irreversibly blocks the H+/K+ ATPase enzyme system (the proton pump) in the gastric parietal cells. This action significantly reduces both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour of administration.
Excretion
Excreted predominantly in the urine (around 90%) and feces (around 10%) as metabolites.
Half life
Approximately 1-2 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 2-4 hours. Bioavailability is approximately 52%.
Metabolism
Extensively metabolized in the liver primarily via cytochrome P450 (CYP2C19 and CYP3A4) isoenzymes.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Patients with known gastrointestinal malignancy (until excluded).
Drug Interactions
Digoxin
Increased absorption and plasma concentration of digoxin.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased plasma levels of methotrexate, especially with high-dose therapy.
Drugs dependent on gastric pH
Ketoconazole, Itraconazole, Atazanavir, Nelfinavir (absorption may be altered due to increased gastric pH).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. In case of overdose, provide symptomatic and supportive treatment. Rabeprazole is not readily dialyzable.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Patients with known gastrointestinal malignancy (until excluded).
Drug Interactions
Digoxin
Increased absorption and plasma concentration of digoxin.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased plasma levels of methotrexate, especially with high-dose therapy.
Drugs dependent on gastric pH
Ketoconazole, Itraconazole, Atazanavir, Nelfinavir (absorption may be altered due to increased gastric pH).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. In case of overdose, provide symptomatic and supportive treatment. Rabeprazole is not readily dialyzable.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, FDA)
Patent Status
Generic available
Clinical Trials
Ongoing clinical research explores rabeprazole's long-term safety, efficacy in specific patient populations, and potential new therapeutic uses.
Lab Monitoring
- Monitor magnesium levels, especially with prolonged use or concomitant use of diuretics.
- Monitor liver function tests periodically.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary to control symptoms.
- Counsel patients on potential long-term risks with PPIs.
- Consider magnesium supplementation for patients at risk of hypomagnesemia.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Swallow the tablet whole; do not crush or chew it.
- Inform your doctor about all other medications you are taking.
- Seek medical attention if symptoms persist or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Rabeprazole may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods, alcohol, and smoking.
- Elevate the head of your bed to help with GERD symptoms.
- Eat smaller, more frequent meals.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.