Raboz
Generic Name
Rabeprazole Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| raboz 20 mg tablet | ৳ 5.00 | N/A |
Description
Overview of the medicine
Raboz 20 mg tablet contains Rabeprazole Sodium, a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat acid-related diseases such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. Duodenal ulcer: 20 mg once daily for 4 weeks. Gastric ulcer: 20 mg once daily for 6 weeks. H. pylori: 20 mg twice daily (with antibiotics).
Elderly
No specific dose adjustment generally needed, but monitor carefully for side effects.
Renal_impairment
No dose adjustment needed for patients with renal impairment.
How to Take
Take orally, preferably in the morning before breakfast. Swallow the tablet whole; do not chew, crush, or break.
Mechanism of Action
Rabeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) in the gastric parietal cells. This action blocks the final step of gastric acid secretion, significantly reducing stomach acid levels.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily via urine (approx. 90%), remainder in feces.
Half life
1-2 hours (though duration of action is much longer due to irreversible binding)
Absorption
Rapidly absorbed, peak plasma concentrations in 2-4 hours. Bioavailability approx. 52%.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Known hypersensitivity to rabeprazole, other benzimidazole derivatives (e.g., omeprazole, lansoprazole), or any component of the formulation.
- •Severe hepatic impairment (use with caution).
Drug Interactions
Digoxin
Increased digoxin levels due to increased gastric pH.
Warfarin
Increased INR/prothrombin time; monitor closely.
Methotrexate
Increased methotrexate levels; monitor for toxicity.
Ketoconazole/Itraconazole
Decreased absorption of these drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and non-specific. Treatment should be symptomatic and supportive. Rabeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit outweighs potential risk to the fetus. Lactation: Not known if rabeprazole is excreted in human milk. Exercise caution when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from the date of manufacture when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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