Rabprazo
Generic Name
Rabeprazole Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rabprazo 20 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Rabeprazole is a proton pump inhibitor (PPI) used to treat conditions caused by too much stomach acid, such as heartburn, stomach ulcers, and gastroesophageal reflux disease (GERD).
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. Duodenal ulcer: 20 mg once daily for 4 weeks. Gastric ulcer: 20 mg once daily for 6 weeks. Zollinger-Ellison Syndrome: Initial 60 mg once daily, adjusted as needed.
Elderly
No dosage adjustment generally required, but caution in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment required.
How to Take
Should be taken orally, preferably in the morning before breakfast. Swallow the tablet whole; do not crush, chew, or split it.
Mechanism of Action
Rabeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells. This reduces the secretion of gastric acid.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Excreted primarily via urine (approximately 90%) and feces.
Half life
Approximately 1 to 2 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 52% and is not significantly affected by food.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, other substituted benzimidazoles, or any component of the formulation.
- Patients taking atazanavir or nelfinavir due to potential reduction in antiretroviral efficacy.
Drug Interactions
Digoxin
Increased bioavailability of digoxin.
Warfarin
Monitor INR; increased risk of bleeding.
Methotrexate
Increased methotrexate levels, especially with high doses.
Ketoconazole/Itraconazole
Decreased absorption of these drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment is symptomatic and supportive. Rabeprazole is not readily dialyzable.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefit outweighs the risk to the fetus. It is not known whether rabeprazole is excreted in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various acid-related disorders.
Lab Monitoring
- Patients on long-term therapy should be monitored for vitamin B12 deficiency.
- Monitor magnesium levels, especially in patients on concomitant diuretics or other drugs that can cause hypomagnesemia.
Doctor Notes
- Consider lowest effective dose for shortest duration for GERD.
- Educate patients on potential long-term risks, especially bone fractures and C. difficile infection.
- Review need for continued therapy periodically.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods, caffeine, and alcohol to reduce symptoms.
- Eat smaller, more frequent meals.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.