radivit-c
Generic Name
Ascorbic Acid (Vitamin C) 1000 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| radivit c 1000 mg tablet | ৳ 16.00 | ৳ 256.00 |
Description
Overview of the medicine
Radivit-C 1000 mg Tablet contains Ascorbic Acid (Vitamin C), an essential water-soluble vitamin. It is vital for immune system function, collagen formation, antioxidant protection, and iron absorption, helping to maintain overall health and prevent deficiencies.
Uses & Indications
Dosage
Adults
For general supplementation: 500 mg to 1000 mg once daily. For acute deficiency (Scurvy): 250-1000 mg daily for several weeks or until symptoms subside, as directed by a physician.
Elderly
No specific dosage adjustment required; generally well-tolerated at adult doses.
Renal_impairment
Use with caution in patients with a history of renal stone formation. High doses may increase oxalate excretion. Consult a physician for appropriate dosing.
How to Take
Take orally, with or without food. It can be taken with food to minimize gastric upset.
Mechanism of Action
Ascorbic acid acts as a potent reducing agent and antioxidant. It is involved in various enzymatic reactions, including collagen synthesis, carnitine synthesis, and neurotransmitter synthesis. It also plays a key role in immune cell function and iron absorption.
Pharmacokinetics
Onset
Effects are typically seen with chronic supplementation, not acute administration for most benefits. Plasma levels peak within 2-3 hours.
Excretion
Excreted primarily by the kidneys as unchanged ascorbic acid and its metabolites. Renal excretion increases with higher doses.
Half life
Plasma half-life varies with dose, ranging from 30 minutes to 3 hours. Body stores determine elimination, with a half-life of 8-40 days for tissue saturation.
Absorption
Readily absorbed from the gastrointestinal tract, primarily in the upper small intestine, through active transport and passive diffusion. Bioavailability decreases with increasing doses.
Metabolism
Partially metabolized in the liver to inactive metabolites, primarily oxalic acid and ascorbate-2-sulfate.
Side Effects
Contraindications
- Hypersensitivity to Ascorbic Acid or any component of the formulation.
- Patients with hyperoxaluria or glucose-6-phosphate dehydrogenase (G6PD) deficiency (especially with high doses).
Drug Interactions
Warfarin
High doses of Vitamin C may interfere with the anticoagulant effect of warfarin. Monitor INR.
Iron supplements
Vitamin C enhances the absorption of non-heme iron from the gut. (Beneficial in iron deficiency, but caution in hemochromatosis).
Aluminum-containing antacids
Vitamin C can increase the absorption of aluminum, potentially leading to aluminum toxicity in patients with renal impairment.
Chelating agents (e.g., deferoxamine)
Can increase iron excretion. Use with caution.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Ascorbic acid is generally non-toxic even at high doses. However, very high doses (e.g., >2 g/day) may cause gastrointestinal upset (diarrhea, nausea, abdominal cramps), increased urination, and in susceptible individuals, may increase the risk of oxalate kidney stone formation. Management is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe at recommended daily allowances. High doses should only be used if clearly needed and under medical supervision.
Side Effects
Contraindications
- Hypersensitivity to Ascorbic Acid or any component of the formulation.
- Patients with hyperoxaluria or glucose-6-phosphate dehydrogenase (G6PD) deficiency (especially with high doses).
Drug Interactions
Warfarin
High doses of Vitamin C may interfere with the anticoagulant effect of warfarin. Monitor INR.
Iron supplements
Vitamin C enhances the absorption of non-heme iron from the gut. (Beneficial in iron deficiency, but caution in hemochromatosis).
Aluminum-containing antacids
Vitamin C can increase the absorption of aluminum, potentially leading to aluminum toxicity in patients with renal impairment.
Chelating agents (e.g., deferoxamine)
Can increase iron excretion. Use with caution.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Ascorbic acid is generally non-toxic even at high doses. However, very high doses (e.g., >2 g/day) may cause gastrointestinal upset (diarrhea, nausea, abdominal cramps), increased urination, and in susceptible individuals, may increase the risk of oxalate kidney stone formation. Management is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe at recommended daily allowances. High doses should only be used if clearly needed and under medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, supermarkets, online stores
Approval Status
Generally Approved (Over-the-counter)
Patent Status
Expired (Generic)
WHO Essential Medicine
YesClinical Trials
Ascorbic acid has been extensively studied for its role in preventing and treating scurvy, its antioxidant properties, and its impact on immune function. Ongoing research explores its potential roles in various chronic diseases.
Lab Monitoring
- No routine lab monitoring is typically required for standard supplementation.
- Patients with specific conditions (e.g., G6PD deficiency, hemochromatosis) may require monitoring of relevant parameters.
Doctor Notes
- Advise patients with a history of renal calculus to limit high-dose Vitamin C intake.
- High doses of Vitamin C may interfere with laboratory tests (e.g., urine glucose, occult blood tests). Inform patients about this potential.
- Consider Vitamin C supplementation in patients with malabsorption syndromes or increased demand (e.g., pregnancy, lactation, stress, smoking).
Patient Guidelines
- Take the tablet whole with water. Do not crush or chew unless it is a chewable tablet.
- Do not exceed the recommended dose without consulting your doctor.
- Inform your healthcare provider about all other medications and supplements you are taking.
- Store in a cool, dry place away from direct sunlight and moisture.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Radivit-C 1000 mg Tablet is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in fruits and vegetables, which are natural sources of Vitamin C.
- Stay well-hydrated, especially when taking higher doses.
- Avoid smoking, as it can deplete Vitamin C levels in the body.
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