Ramilon
Generic Name
Ramilon Hydrochloride
Manufacturer
Hypo Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ramilon 25 mg tablet | ৳ 4.00 | N/A |
Description
Overview of the medicine
Ramilon 25 mg Tablet is an antidepressant medicine used to treat various mental health conditions such as major depressive disorder, generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder.
Uses & Indications
Dosage
Adults
Initial dose 25 mg orally once daily. May be increased to 50 mg after one week, then gradually up to 100-200 mg daily based on clinical response and tolerability. Doses above 200 mg are not recommended.
Elderly
Start with a lower initial dose (e.g., 12.5 mg or 25 mg every other day) and titrate slowly due to potential increased sensitivity and reduced clearance. Maximum 100 mg daily.
Renal_impairment
No specific dose adjustment is typically required for mild to moderate renal impairment. Use with caution in severe renal impairment (CrCl < 30 mL/min) and monitor closely.
How to Take
Ramilon 25 mg Tablet should be taken orally once daily, with or without food. It is advisable to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Ramilon works by selectively inhibiting the reuptake of serotonin in the central nervous system, thereby enhancing serotonergic neurotransmission. This helps to improve mood and reduce anxiety.
Pharmacokinetics
Onset
Initial therapeutic effects may be noticed in 1-2 weeks, but full antidepressant effect may take 2-4 weeks or longer.
Excretion
Mainly excreted in urine and feces as metabolites, with less than 5% as unchanged drug.
Half life
Approximately 20-24 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, with peak plasma concentrations occurring within 4-8 hours. Bioavailability is high.
Metabolism
Extensively metabolized in the liver, primarily via CYP450 enzymes (e.g., CYP2D6, CYP2C19) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ramilon or any other SSRI or component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI. A 14-day washout period is also required before starting an MAOI after Ramilon.
- Concomitant use with Pimozide.
- Uncontrolled narrow-angle glaucoma.
Drug Interactions
MAOIs
Concurrent use may lead to serious, sometimes fatal, reactions including serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability).
Triptans
Increased risk of serotonin syndrome.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Diuretics
Increased risk of hyponatremia.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding when co-administered.
Other CNS depressants
Additive sedative effects.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiry date.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, dizziness, and seizures. There is no specific antidote. Management involves supportive care, maintaining an open airway, cardiac monitoring, and symptomatic treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to SSRIs late in the third trimester have developed complications requiring prolonged hospitalization. Ramilon is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Ramilon or any other SSRI or component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping an MAOI. A 14-day washout period is also required before starting an MAOI after Ramilon.
- Concomitant use with Pimozide.
- Uncontrolled narrow-angle glaucoma.
Drug Interactions
MAOIs
Concurrent use may lead to serious, sometimes fatal, reactions including serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability).
Triptans
Increased risk of serotonin syndrome.
Warfarin
May enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Diuretics
Increased risk of hyponatremia.
NSAIDs/Aspirin
Increased risk of gastrointestinal bleeding when co-administered.
Other CNS depressants
Additive sedative effects.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not use after the expiry date.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, dizziness, and seizures. There is no specific antidote. Management involves supportive care, maintaining an open airway, cardiac monitoring, and symptomatic treatment. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to SSRIs late in the third trimester have developed complications requiring prolonged hospitalization. Ramilon is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ramilon has undergone various clinical trials demonstrating its efficacy and safety profile in the treatment of major depressive disorder, anxiety disorders, and other psychiatric conditions in adult populations. Further studies may be ongoing for specific populations or new indications.
Lab Monitoring
- Monitor for sodium levels, especially in elderly patients or those on diuretics, due to the risk of hyponatremia.
- Monitor coagulation parameters (e.g., INR) if co-administered with anticoagulants like warfarin.
- Liver function tests may be considered in patients with pre-existing hepatic impairment or if symptoms of liver dysfunction develop.
Doctor Notes
- Emphasize to patients the importance of adherence and not discontinuing the medication abruptly.
- Monitor for emergent suicidality, particularly during the initial phase of treatment or dose adjustments.
- Advise patients about potential delayed onset of action and management of common side effects.
- Consider drug interactions, especially with other CNS-active agents, MAOIs, and anticoagulants.
Patient Guidelines
- Do not stop taking Ramilon abruptly without consulting your doctor, as it can lead to withdrawal symptoms.
- It may take several weeks for the full therapeutic effects to be observed. Continue taking the medication as prescribed.
- Avoid alcohol consumption while on Ramilon, as it can worsen side effects and impair cognitive function.
- Report any new or worsening symptoms, especially changes in mood, behavior, or suicidal ideation, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ramilon may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medication affects you and are certain you can perform such activities safely.
Lifestyle Advice
- Incorporate regular physical activity into your routine to help manage mood and energy levels.
- Maintain a balanced diet and adequate hydration.
- Practice stress-reduction techniques such as mindfulness, meditation, or deep breathing exercises.
- Ensure sufficient and consistent sleep.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Ramilon Brand
Other medicines available under the same brand name
