Ranzo
Generic Name
Rabeprazole 20 mg
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ranzo 20 mg capsule | ৳ 4.00 | N/A |
Description
Overview of the medicine
Rabeprazole is a proton pump inhibitor used to treat conditions involving excessive stomach acid, such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. Peptic Ulcer: 20 mg once daily for 4-6 weeks. H. pylori eradication: 20 mg twice daily with antibiotics.
Elderly
No specific dosage adjustment is usually required, but caution is advised in very elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally, usually before a meal. Swallow the capsule whole with water; do not chew or crush it.
Mechanism of Action
It works by blocking the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby reducing the secretion of gastric acid.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted via urine (approximately 90%) and feces (approximately 10%).
Half life
Approximately 1-2 hours.
Absorption
Rapidly absorbed after oral administration, with a bioavailability of approximately 52%.
Metabolism
Extensively metabolized in the liver mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole or any other substituted benzimidazoles (e.g., omeprazole, lansoprazole).
- Known hypersensitivity to any component of the formulation.
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
Increased INR and prothrombin time.
Methotrexate
Increased methotrexate levels, especially with high doses.
Ketoconazole/Itraconazole
Decreased absorption of these drugs due to increased gastric pH.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Not recommended during breastfeeding due to potential excretion in breast milk. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole or any other substituted benzimidazoles (e.g., omeprazole, lansoprazole).
- Known hypersensitivity to any component of the formulation.
Drug Interactions
Digoxin
May increase digoxin levels.
Warfarin
Increased INR and prothrombin time.
Methotrexate
Increased methotrexate levels, especially with high doses.
Ketoconazole/Itraconazole
Decreased absorption of these drugs due to increased gastric pH.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Not recommended during breastfeeding due to potential excretion in breast milk. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Expired
Clinical Trials
Rabeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of GERD, peptic ulcers, and H. pylori eradication.
Lab Monitoring
- No routine lab monitoring is generally required. However, magnesium levels may be monitored in patients on long-term therapy (over 1 year).
Doctor Notes
- Advise patients on the importance of completing the full course of treatment.
- Educate patients about potential long-term risks with PPIs and monitor for symptoms of hypomagnesemia or B12 deficiency.
- Consider potential drug interactions, especially with warfarin, digoxin, and methotrexate.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about any unusual or severe side effects.
- Complete the full course of treatment even if symptoms improve.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness, drowsiness, or blurred vision. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid spicy, fatty foods, caffeine, and alcohol, as they can worsen acid reflux.
- Eat smaller, more frequent meals instead of large ones.
- Avoid lying down immediately after eating.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.