Rashnil
Generic Name
Desloratadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rashnil 40 ointment | ৳ 50.00 | N/A |
Description
Overview of the medicine
Rashnil (Desloratadine) is a long-acting tricyclic antihistamine with selective H1-receptor antagonist activity. It is indicated for the symptomatic relief of seasonal allergic rhinitis, perennial allergic rhinitis, and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and over: 5 mg (one tablet) once daily.
Elderly
No dosage adjustment is generally required for elderly patients, but caution is advised in cases of severe renal or hepatic impairment.
Renal_impairment
For patients with severe renal impairment, a starting dose of 5 mg every other day is recommended.
How to Take
Oral administration, with or without food.
Mechanism of Action
Desloratadine is a selective peripheral H1-receptor antagonist. It inhibits the release of histamine from mast cells and blocks the binding of histamine to H1 receptors, thereby alleviating allergic symptoms such as sneezing, rhinorrhea, nasal itching, and ocular itching. It also has anti-inflammatory properties.
Pharmacokinetics
Onset
Onset of action within 1 hour.
Excretion
Eliminated primarily via urine and feces as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached approximately 3 hours after dosing.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increases plasma concentration of desloratadine (not clinically significant).
Erythromycin
Increases plasma concentration of desloratadine (not clinically significant).
Ketoconazole
Increases plasma concentration of desloratadine (not clinically significant).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increases plasma concentration of desloratadine (not clinically significant).
Erythromycin
Increases plasma concentration of desloratadine (not clinically significant).
Ketoconazole
Increases plasma concentration of desloratadine (not clinically significant).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Desloratadine is excreted into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA & DGDA
Patent Status
Patent expired, generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of desloratadine in treating allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No routine laboratory monitoring is required for desloratadine.
Doctor Notes
- Counsel patients on the non-sedating nature of desloratadine, but advise caution with activities requiring alertness until individual response is known.
- Emphasize adherence to the once-daily dosing regimen for optimal efficacy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rashnil is generally non-sedating; however, individual responses may vary. Patients should be advised to determine their response to the drug before engaging in activities requiring mental alertness, such as driving or operating machinery.
Lifestyle Advice
- Avoid exposure to known allergens that trigger your symptoms.
- Maintain a healthy lifestyle with adequate rest and hydration.
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