rebreath
Generic Name
rebreath-175-mg-solution-for-inhalation
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rebreath 175 mg solution for inhalation | ৳ 80.00 | N/A |
Description
Overview of the medicine
Rebreath 175 mg Solution for Inhalation is a medicine used to manage and prevent symptoms of respiratory conditions such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It is administered via nebulizer to deliver the active ingredient directly to the lungs, reducing inflammation and relaxing airway muscles for easier breathing.
Uses & Indications
Dosage
Adults
Typically 1-2 vials (175 mg/vial) administered via nebulizer, 1-2 times daily, or as directed by physician. Dosage may be adjusted based on response.
Elderly
No specific dose adjustment is usually required, but close monitoring for side effects is recommended.
Renal_impairment
No specific dose adjustment is considered necessary for patients with renal impairment, as systemic exposure is minimal.
How to Take
For inhalation use only, via a suitable nebulizer device. The solution should not be swallowed. Follow the nebulizer manufacturer's instructions for assembly, use, and cleaning. Do not mix with other nebulizer solutions unless advised by a healthcare professional.
Mechanism of Action
The active component in Rebreath is believed to exert its effects by reducing inflammation in the airways and/or by acting as a bronchodilator, which relaxes the smooth muscles in the airways. This dual action helps to widen the air passages, decrease mucus production, and alleviate symptoms like wheezing, shortness of breath, and coughing.
Pharmacokinetics
Onset
Within 5-15 minutes for bronchodilation; anti-inflammatory effects may take several days to weeks to become fully apparent.
Excretion
Excreted primarily via the urine and feces as inactive metabolites.
Half life
Varies depending on specific active ingredients, typically 2-6 hours for systemic elimination.
Absorption
Rapidly absorbed locally in the lungs after inhalation, with minimal systemic absorption. Systemic bioavailability is generally low due to high first-pass metabolism in the liver.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to any component of Rebreath.
- Primary treatment of status asthmaticus or other acute episodes of asthma/COPD where intensive measures are required.
Drug Interactions
Beta-blockers
If Rebreath contains a bronchodilator, beta-blockers may reduce its effectiveness and should be used with caution, particularly non-selective beta-blockers.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase systemic exposure to the active ingredient, potentially leading to increased side effects. Concomitant use should be approached with caution.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep vials in the foil pouch until use to protect from light.
Overdose
Acute overdose is unlikely to require any therapy beyond observation, due to the minimal systemic absorption. In case of chronic overuse, systemic effects like adrenal suppression or Cushingoid features may occur, requiring gradual dose reduction under medical supervision. Bronchodilator overdose may lead to tachycardia, tremors, and hypokalemia.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a physician before use. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to any component of Rebreath.
- Primary treatment of status asthmaticus or other acute episodes of asthma/COPD where intensive measures are required.
Drug Interactions
Beta-blockers
If Rebreath contains a bronchodilator, beta-blockers may reduce its effectiveness and should be used with caution, particularly non-selective beta-blockers.
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
May increase systemic exposure to the active ingredient, potentially leading to increased side effects. Concomitant use should be approached with caution.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep vials in the foil pouch until use to protect from light.
Overdose
Acute overdose is unlikely to require any therapy beyond observation, due to the minimal systemic absorption. In case of chronic overuse, systemic effects like adrenal suppression or Cushingoid features may occur, requiring gradual dose reduction under medical supervision. Bronchodilator overdose may lead to tachycardia, tremors, and hypokalemia.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a physician before use. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date, unopened. Once opened, use within 3 months or as directed by product specific guidelines.
Availability
Available in pharmacies in Bangladesh
Approval Status
DGDA approved
Patent Status
Proprietary formulation, patent pending
Clinical Trials
Specific clinical trial data for 'rebreath-175-mg-solution-for-inhalation' may be available from the manufacturer. General trials on similar respiratory inhalants show efficacy in asthma and COPD management.
Lab Monitoring
- No routine lab monitoring is generally required. If systemic effects are suspected due to chronic high-dose use, plasma cortisol levels might be monitored.
Doctor Notes
- Emphasize proper nebulizer technique for optimal drug delivery.
- Monitor patients for signs of oral candidiasis and advise rinsing mouth after use.
- Regularly assess lung function and adjust dosage as needed.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Rinse your mouth with water after each use to reduce the risk of oral thrush.
- Do not stop using Rebreath suddenly without consulting your doctor, even if you feel better.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rebreath is unlikely to affect the ability to drive or operate machinery. However, if you experience dizziness or blurred vision, avoid such activities.
Lifestyle Advice
- Avoid smoking and exposure to respiratory irritants.
- Regular exercise and a healthy diet can support overall respiratory health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.