Recelbia
Generic Name
Monoclonal Antibody (hypothetical)
Manufacturer
BioGen Pharmaceuticals Inc.
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| recelbia 10 mg injection | ৳ 12,000.00 | N/A |
Description
Overview of the medicine
Recelbia 10 mg Injection is a targeted biologic therapy used for the treatment of certain autoimmune conditions. It works by specifically blocking the activity of Interleukin-6 (IL-6), a cytokine involved in inflammation and immune response. This helps to reduce inflammation and manage disease progression.
Uses & Indications
Dosage
Adults
For Rheumatoid Arthritis: 10 mg administered subcutaneously every week, or 20 mg every two weeks. Dosage may be adjusted based on clinical response and tolerability.
Elderly
No specific dosage adjustment is required for elderly patients (≥65 years of age). However, monitor for adverse reactions.
Renal_impairment
No specific dose adjustment is needed for mild to moderate renal impairment. Use with caution in severe renal impairment.
How to Take
Recelbia is administered as a subcutaneous injection. Patients may be taught to self-inject after proper training by a healthcare professional. Inject into the abdomen, thigh, or upper arm. Rotate injection sites.
Mechanism of Action
Recelbia is a recombinant humanized monoclonal antibody that selectively binds to both soluble and membrane-bound IL-6 receptors, thereby inhibiting IL-6-mediated signaling. IL-6 is a pleiotropic cytokine that plays a key role in various inflammatory and autoimmune diseases.
Pharmacokinetics
Onset
Clinical effects may be observed within 2-4 weeks.
Excretion
Degradation products are mainly eliminated via renal and reticuloendothelial system.
Half life
Approximately 11-13 days (dose-dependent).
Absorption
Following subcutaneous administration, peak serum concentrations are reached in 2-3 days. Bioavailability is approximately 80%.
Metabolism
Primarily eliminated via non-specific proteolytic degradation (catabolism) of antibodies, rather than through cytochrome P450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Recelbia or any of its excipients.
- Active severe infections (e.g., tuberculosis, sepsis).
Drug Interactions
Live Vaccines
Avoid co-administration with live vaccines as the immune response may be impaired.
CYP450 Substrates
Recelbia may normalize hepatic CYP450 activity, potentially altering metabolism of drugs metabolized by CYP3A4, CYP2C9, CYP2C19, or CYP2D6. Monitor patients taking such drugs (e.g., Warfarin, Cyclosporine, Statins) for altered effects.
Storage
Store in a refrigerator (2°C to 8°C). Do not freeze. Protect from light. Do not shake. Keep out of reach of children.
Overdose
There is no specific antidote for Recelbia overdose. In case of an overdose, patients should be closely monitored for signs and symptoms of adverse reactions and appropriate symptomatic treatment should be initiated.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Recelbia is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored as recommended.
Availability
Available in pharmacies and hospitals with a prescription.
Approval Status
Approved by regulatory bodies in various countries.
Patent Status
Under patent protection
Clinical Trials
Recelbia has undergone extensive Phase 1, 2, and 3 clinical trials demonstrating its efficacy and safety in indicated patient populations. Key trials include 'ASCEND-RA' for Rheumatoid Arthritis and 'PIONEER-SJIA' for Systemic Juvenile Idiopathic Arthritis.
Lab Monitoring
- Complete blood count (CBC) before initiation, 4-8 weeks after initiation, and every 3 months thereafter.
- Liver function tests (ALT, AST) before initiation, 4-8 weeks after initiation, and every 3 months thereafter.
- Lipid panel (total cholesterol, HDL, LDL, triglycerides) at baseline and 4-8 weeks after initiation.
Doctor Notes
- Prior to initiation, screen patients for latent tuberculosis and viral hepatitis.
- Monitor absolute neutrophil count (ANC) and platelet count regularly.
- Educate patients on proper self-injection technique and signs of infection.
Patient Guidelines
- Report any signs of infection (fever, chills, persistent cough) immediately to your doctor.
- Do not receive live vaccines while on Recelbia treatment.
- Inform your doctor about all medications, supplements, and herbal products you are taking.
- Store the injection in the refrigerator and protect from light.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it's close to the next scheduled dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Recelbia is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to reduce infection risk.
- Follow a balanced diet and engage in regular, moderate exercise as advised by your doctor.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.