Reclevus
Generic Name
Reclecoxib
Manufacturer
Rec Pharma Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reclevus 50 mg tablet | ৳ 17.50 | ৳ 175.00 |
Description
Overview of the medicine
Reclevus 50 mg tablet contains Reclecoxib, a selective COX-2 inhibitor used to relieve pain, inflammation, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
For osteoarthritis, 50 mg once daily. For rheumatoid arthritis, 50 mg twice daily. For acute pain, 50 mg as needed, not exceeding 100 mg per day.
Elderly
No specific dose adjustment is required, but use with caution due to increased risk of adverse effects.
Renal_impairment
Mild to moderate impairment: No dose adjustment. Severe impairment: Not recommended.
How to Take
Take orally with or without food. Swallowing the tablet whole with a glass of water is recommended.
Mechanism of Action
Reclecoxib selectively inhibits cyclooxygenase-2 (COX-2), an enzyme responsible for the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. By inhibiting COX-2, Reclecoxib reduces prostaglandin production, thereby alleviating symptoms.
Pharmacokinetics
Onset
Pain relief typically begins within 1 hour, with full therapeutic effect within 1-2 days.
Excretion
Excreted primarily via urine and feces, with less than 1% as unchanged drug.
Half life
Approximately 8-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 2-3 hours after oral administration.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C9).
Side Effects
Contraindications
- Hypersensitivity to Reclecoxib or other sulfonamides
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe heart failure
- Active gastrointestinal bleeding or ulceration
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity. Monitor lithium levels.
Warfarin
May enhance the anticoagulant effect, increasing the risk of bleeding. Monitor INR.
Furosemide
May reduce natriuretic effect.
Methotrexate
May increase plasma methotrexate concentrations, enhancing toxicity.
Diuretics and ACE inhibitors
May reduce the natriuretic and antihypertensive effects. Monitor blood pressure and renal function.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding can occur. Supportive care and symptomatic treatment are recommended. No specific antidote is available.
Pregnancy & Lactation
Use during pregnancy, especially in the third trimester, is contraindicated due to potential fetal harm. Avoid use during lactation as Reclecoxib may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Reclecoxib or other sulfonamides
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Severe heart failure
- Active gastrointestinal bleeding or ulceration
- Third trimester of pregnancy
Drug Interactions
Lithium
May increase plasma lithium levels, leading to toxicity. Monitor lithium levels.
Warfarin
May enhance the anticoagulant effect, increasing the risk of bleeding. Monitor INR.
Furosemide
May reduce natriuretic effect.
Methotrexate
May increase plasma methotrexate concentrations, enhancing toxicity.
Diuretics and ACE inhibitors
May reduce the natriuretic and antihypertensive effects. Monitor blood pressure and renal function.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Gastrointestinal bleeding can occur. Supportive care and symptomatic treatment are recommended. No specific antidote is available.
Pregnancy & Lactation
Use during pregnancy, especially in the third trimester, is contraindicated due to potential fetal harm. Avoid use during lactation as Reclecoxib may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities
Patent Status
Under patent protection
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Reclecoxib in managing pain and inflammation in various arthritic conditions.
Lab Monitoring
- Complete Blood Count (CBC) (for anemia)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Advise patients on potential cardiovascular and GI risks.
- Monitor renal and hepatic function, especially in elderly or high-risk patients.
- Prescribe the lowest effective dose for the shortest duration necessary.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, stomach pain, or black stools immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Exercise caution when driving or operating machinery until you know how Reclevus affects you.
Lifestyle Advice
- Maintain a balanced diet.
- Engage in regular, moderate exercise if appropriate for your condition.
- Avoid excessive alcohol consumption.
- Quit smoking to reduce cardiovascular risks.
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