Recof
Generic Name
Dextromethorphan Hydrobromide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| recof 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Recof-15 mg Syrup is an antitussive medication used for the symptomatic relief of dry, unproductive coughs by suppressing the cough reflex.
Uses & Indications
Dosage
Adults
10-20 mg (5-10 ml) every 4-6 hours as needed, not to exceed 120 mg (60 ml) in 24 hours.
Elderly
Similar to adult dosage, but use with caution due to potential for increased sensitivity.
Renal_impairment
Use with caution. Dosage adjustment may be necessary in severe renal impairment. Consult a physician.
How to Take
Administer orally, with or without food. Use a measuring device for accurate dosing.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla oblongata to elevate the cough threshold, thereby suppressing the cough reflex.
Pharmacokinetics
Onset
15-30 minutes
Excretion
Mainly excreted by the kidneys as unchanged drug and metabolites.
Half life
Approximately 1.4 to 3.9 hours for dextromethorphan; active metabolite dextrorphan has a longer half-life (10-19 hours).
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6, to its active metabolite dextrorphan.
Side Effects
Contraindications
- Hypersensitivity to dextromethorphan or any component of the syrup
- Patients currently taking or who have taken Monoamine Oxidase Inhibitors (MAOIs) within the last 14 days, due to risk of serotonin syndrome
- Patients with productive cough (unless advised by a doctor)
- Asthma and other conditions where cough is beneficial
Drug Interactions
SSRIs and TCAs
Increased risk of serotonin syndrome.
Alcohol and other CNS depressants
May enhance CNS depressant effects like drowsiness and dizziness.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use can lead to serotonin syndrome (hyperthermia, rigidity, mental status changes). Avoid use within 14 days of MAOI cessation.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
Can increase dextromethorphan plasma concentrations, leading to increased effects and side effects.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, drowsiness, dizziness, ataxia, nystagmus, blurred vision, respiratory depression, and serotonin syndrome (agitation, confusion, tachycardia). Treatment is supportive, and severe cases may require naloxone.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if potential benefit outweighs potential risk, and under medical supervision. Dextromethorphan is excreted into breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to dextromethorphan or any component of the syrup
- Patients currently taking or who have taken Monoamine Oxidase Inhibitors (MAOIs) within the last 14 days, due to risk of serotonin syndrome
- Patients with productive cough (unless advised by a doctor)
- Asthma and other conditions where cough is beneficial
Drug Interactions
SSRIs and TCAs
Increased risk of serotonin syndrome.
Alcohol and other CNS depressants
May enhance CNS depressant effects like drowsiness and dizziness.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use can lead to serotonin syndrome (hyperthermia, rigidity, mental status changes). Avoid use within 14 days of MAOI cessation.
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
Can increase dextromethorphan plasma concentrations, leading to increased effects and side effects.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, drowsiness, dizziness, ataxia, nystagmus, blurred vision, respiratory depression, and serotonin syndrome (agitation, confusion, tachycardia). Treatment is supportive, and severe cases may require naloxone.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if potential benefit outweighs potential risk, and under medical supervision. Dextromethorphan is excreted into breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
Clinical Trials
Dextromethorphan is a well-established antitussive, extensively studied over decades. Further clinical trials may focus on new formulations, combinations, or specific patient populations.
Lab Monitoring
- No specific lab monitoring is typically required for routine use.
Doctor Notes
- Advise patients about potential for drowsiness and to avoid alcohol.
- Carefully assess cough type (dry vs. productive) before recommending.
- Caution against use in patients on MAOIs or certain antidepressants due to serotonin syndrome risk.
- Educate on proper dosing to prevent misuse/abuse.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- Consult a doctor if cough persists for more than 7 days, recurs, or is accompanied by fever, rash, or persistent headache.
- Do not use for chronic cough associated with smoking, asthma, or emphysema, or if cough is accompanied by excessive phlegm, unless directed by a doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness or dizziness. Exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Use humidifiers to keep the air moist.
- Avoid exposure to irritants like smoke and dust.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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