Recogen
Generic Name
Human Chorionic Gonadotropin (HCG)
Manufacturer
PharmaGen Inc.
Country
Global
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| recogen 5000 iu injection | ৳ 2,557.00 | N/A |
Description
Overview of the medicine
Recogen 5000 IU Injection is a form of Human Chorionic Gonadotropin (HCG), a hormone that supports the normal development of an egg in a woman's ovary, and stimulates its release during ovulation. In men, it is used to increase sperm count and treat undescended testicles.
Uses & Indications
Dosage
Adults
Female Infertility: 5000-10000 IU administered one day after the last dose of menotropins or FSH. Male Hypogonadism: 500-4000 IU three times weekly for several weeks or months. Cryptorchidism: 1000-5000 IU three times weekly for 4-6 weeks.
Elderly
No specific dose adjustment is generally required, but caution should be exercised in elderly patients with pre-existing cardiovascular disease.
Renal_impairment
No specific dosage adjustments are typically required, but monitoring is advised.
How to Take
Recogen 5000 IU Injection is administered by intramuscular (IM) or subcutaneous (SC) injection after reconstitution with the provided solvent. The injection site should be rotated to prevent lipoatrophy.
Mechanism of Action
HCG is an LH (Luteinizing Hormone) analog. It binds to LH receptors in the gonads, stimulating steroidogenesis. In women, it induces ovulation and maintains the corpus luteum. In men, it stimulates Leydig cells to produce testosterone and promotes spermatogenesis.
Pharmacokinetics
Onset
Ovulation typically occurs within 36-40 hours after HCG administration in women.
Excretion
Mainly excreted by the kidneys, with approximately 10-12% excreted unchanged in urine.
Half life
Biphasic elimination. Initial half-life is approximately 11 hours, followed by a slower phase of approximately 2-3 days.
Absorption
Rapidly and well absorbed following intramuscular (IM) or subcutaneous (SC) administration. Peak plasma concentrations are reached within 6-16 hours for IM and 6-16 hours for SC.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to HCG or any excipients.
- Uncontrolled thyroid or adrenal dysfunction.
- Primary gonadal failure (e.g., ovarian failure, testicular agenesis).
- Presence of androgen-dependent tumors (e.g., prostate carcinoma, breast carcinoma in males).
- Unexplained vaginal bleeding.
- Pregnancy or lactation (when used for fertility treatment).
Drug Interactions
Other fertility drugs
May be used with other fertility medications (e.g., FSH, menotropins), but close monitoring is essential.
GnRH agonists/antagonists
Used in conjunction with GnRH analogs, careful monitoring of ovarian response is required.
Storage
Store in a refrigerator at 2°C to 8°C. Protect from light. Do not freeze. After reconstitution, the solution should be used immediately. If not, it can be stored for up to 24 hours at 2°C to 8°C.
Overdose
Overdose in women may lead to Ovarian Hyperstimulation Syndrome (OHSS), characterized by severe abdominal pain, bloating, nausea, vomiting, and weight gain. In men, excessive androgenic effects or gynecomastia may occur. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category X: HCG is used to achieve pregnancy, but is contraindicated once pregnancy is established. Not recommended for use during lactation due to potential passage into breast milk and effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored correctly. Refer to the specific product packaging for exact details.
Availability
Hospitals, Clinics, Pharmacies specializing in fertility treatment
Approval Status
Approved (e.g., FDA, EMA, DGDA)
Patent Status
Generic, patents expired
WHO Essential Medicine
YesClinical Trials
HCG has been extensively studied in numerous clinical trials for its efficacy in fertility treatment and other endocrine disorders. Ongoing research continues to optimize its use and understand its broader implications.
Lab Monitoring
- Serum estradiol levels (females, during ovarian stimulation).
- Ovarian ultrasound (females, to monitor follicle development and OHSS risk).
- Serum testosterone levels (males, during treatment for hypogonadism).
Doctor Notes
- Crucial for fertility specialists to monitor patients closely, especially women undergoing ovarian stimulation, for signs of OHSS.
- Patients must be educated on proper administration techniques if self-injecting and on symptoms requiring immediate medical attention.
- Not indicated for weight reduction.
Patient Guidelines
- Follow your doctor's instructions precisely regarding dosage and administration.
- Report any severe abdominal pain, bloating, or sudden weight gain immediately to your doctor, as these could be signs of OHSS.
- Do not use this medicine for weight loss purposes, as it is ineffective and carries risks.
- Ensure proper disposal of used needles and syringes.
Missed Dose Advice
If a dose is missed, contact your doctor for advice. Do not double the dose to compensate for a missed dose.
Driving Precautions
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience side effects like headache or dizziness, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and lifestyle as advised by your healthcare provider to support fertility treatment.
- Avoid strenuous physical activity if you are at risk of OHSS.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.