Reconil
Generic Name
Pregabalin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reconil 200 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Reconil 200 mg Tablet contains Pregabalin, which is used to treat neuropathic pain, epilepsy (partial onset seizures), and generalized anxiety disorder. It helps by calming damaged nerves and reducing abnormal electrical activity in the brain.
Uses & Indications
Dosage
Adults
For neuropathic pain: Initial 150 mg/day in 2-3 divided doses; may increase up to 300 mg/day after 3-7 days, maximum 600 mg/day. For epilepsy/GAD: Initial 150 mg/day in 2-3 divided doses; may increase up to 300 mg/day after 1 week, maximum 600 mg/day.
Elderly
Dose adjustment may be necessary due to potential for decreased renal function; careful monitoring is advised.
Renal_impairment
Dose adjustment is required based on creatinine clearance (e.g., lower doses for severe impairment).
How to Take
Reconil 200 mg Tablet should be taken orally with or without food. It should be swallowed whole with water.
Mechanism of Action
Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the release of several excitatory neurotransmitters, such as glutamate, noradrenaline, and substance P, thereby reducing neuronal excitability and pain signals.
Pharmacokinetics
Onset
Within 1 week for pain and anxiety; longer for epilepsy.
Excretion
Primarily excreted unchanged in the urine; renal elimination is the major route.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached within 1.5 hours. Oral bioavailability is >90% and is independent of dose.
Metabolism
Negligible systemic metabolism (less than 2% of the dose is metabolized).
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients in the formulation.
Drug Interactions
Thiazolidinediones (e.g., pioglitazone)
Increased risk of weight gain and peripheral edema when co-administered.
CNS depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance the sedative effects of pregabalin and increase the risk of respiratory depression.
Storage
Store below 30°C, in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Treatment is supportive and symptomatic; hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients in the formulation.
Drug Interactions
Thiazolidinediones (e.g., pioglitazone)
Increased risk of weight gain and peripheral edema when co-administered.
CNS depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance the sedative effects of pregabalin and increase the risk of respiratory depression.
Storage
Store below 30°C, in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Treatment is supportive and symptomatic; hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of pregabalin for its approved indications, including studies on neuropathic pain, epilepsy, and generalized anxiety disorder. Post-marketing surveillance data continue to be collected.
Lab Monitoring
- Monitor renal function (creatinine clearance) in elderly patients or those with renal impairment.
- Periodically assess for signs of suicidal ideation or unusual behavioral changes.
Doctor Notes
- Prescribe with caution in patients with renal impairment; dose adjustment is crucial.
- Monitor patients for signs of suicidal ideation, especially during initial therapy or dose changes.
- Advise patients on the importance of gradual tapering when discontinuing the medication to avoid withdrawal symptoms.
Patient Guidelines
- Do not stop taking Reconil abruptly, as it may lead to withdrawal symptoms.
- Avoid driving or operating heavy machinery until you know how the medication affects you.
- Report any unusual mood changes, depression, or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Reconil may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Patients should be advised not to drive or operate complex machinery until they are certain that pregabalin does not affect their ability.
Lifestyle Advice
- Avoid alcohol consumption while taking Reconil, as it can worsen side effects like dizziness and somnolence.
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
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Global Brand Names
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