Recox
Generic Name
Etoricoxib
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| recox 90 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Recox 90 mg Tablet contains Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis.
Uses & Indications
Dosage
Adults
Osteoarthritis: 30 mg or 60 mg once daily. Rheumatoid Arthritis, Ankylosing Spondylitis: 90 mg once daily. Acute Gouty Arthritis: 120 mg once daily for a maximum of 8 days. Acute Pain: 120 mg once daily for a maximum of 8 days.
Elderly
No dosage adjustment is generally required, but caution is advised. Initiate at the lowest effective dose.
Renal_impairment
Severe renal impairment (creatinine clearance <30 mL/min) is a contraindication. For moderate impairment (creatinine clearance 30-60 mL/min), caution is advised.
How to Take
Recox tablets should be swallowed whole with a glass of water, with or without food. Taking it with food may help reduce stomach upset.
Mechanism of Action
Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, mediators of pain and inflammation. By inhibiting COX-2, it reduces prostaglandin production, thereby alleviating pain and inflammation.
Pharmacokinetics
Onset
Pain relief typically begins within 24 minutes to 1 hour.
Excretion
Approximately 70% of the dose is excreted in the urine and 20% in the feces as metabolites.
Half life
Approximately 22 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations achieved in approximately 1 hour. Oral bioavailability is about 100%.
Metabolism
Extensively metabolized in the liver, primarily via cytochrome P450 enzymes (mainly CYP3A4), forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to etoricoxib or any component of the tablet
- Active peptic ulceration or gastrointestinal (GI) bleeding
- Severe hepatic dysfunction
- Severe renal impairment (creatinine clearance <30 mL/min)
- Inflammatory bowel disease
- Congestive heart failure (NYHA II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased prothrombin time/INR, increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Rifampicin
Decreased etoricoxib plasma concentrations.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Oral Contraceptives
Increased plasma concentrations of ethinyl estradiol, potentially affecting efficacy.
Cyclosporine/Tacrolimus
Increased nephrotoxicity.
ACE Inhibitors/Angiotensin II Receptor Antagonists (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally consistent with the known adverse effects of etoricoxib (e.g., gastrointestinal events, renal toxicity, cardiovascular events). Management should be symptomatic and supportive, including removal of unabsorbed drug, and monitoring vital signs and organ function.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to potential adverse effects on fetal cardiovascular system. Avoid during the first and second trimesters unless absolutely necessary. Lactation: Not recommended during breastfeeding as etoricoxib is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to etoricoxib or any component of the tablet
- Active peptic ulceration or gastrointestinal (GI) bleeding
- Severe hepatic dysfunction
- Severe renal impairment (creatinine clearance <30 mL/min)
- Inflammatory bowel disease
- Congestive heart failure (NYHA II-IV)
- Established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Warfarin
Increased prothrombin time/INR, increased risk of bleeding.
Diuretics
Reduced diuretic and antihypertensive effects.
Rifampicin
Decreased etoricoxib plasma concentrations.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Oral Contraceptives
Increased plasma concentrations of ethinyl estradiol, potentially affecting efficacy.
Cyclosporine/Tacrolimus
Increased nephrotoxicity.
ACE Inhibitors/Angiotensin II Receptor Antagonists (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally consistent with the known adverse effects of etoricoxib (e.g., gastrointestinal events, renal toxicity, cardiovascular events). Management should be symptomatic and supportive, including removal of unabsorbed drug, and monitoring vital signs and organ function.
Pregnancy & Lactation
Pregnancy: Contraindicated in the third trimester due to potential adverse effects on fetal cardiovascular system. Avoid during the first and second trimesters unless absolutely necessary. Lactation: Not recommended during breastfeeding as etoricoxib is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired for generic versions
Clinical Trials
Etoricoxib has undergone extensive clinical trials for its efficacy and safety in various inflammatory and pain conditions. Ongoing research continues to explore its long-term cardiovascular safety profile.
Lab Monitoring
- Liver function tests (baseline and periodically, especially with long-term use)
- Renal function tests (baseline and periodically, especially in patients with pre-existing renal impairment)
- Blood pressure monitoring
- Complete blood count
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with individual patient treatment goals.
- Monitor patients for signs of cardiovascular and gastrointestinal adverse events, especially in those with pre-existing risk factors.
- Consider alternative treatments for patients with high cardiovascular risk or history of severe GI events.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual symptoms, especially severe stomach pain, black stools, or signs of heart problems (e.g., chest pain, shortness of breath) to your doctor immediately.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking this medication.
- Maintain a healthy lifestyle with a balanced diet and regular exercise to support overall well-being.
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