Reducid
Generic Name
Esomeprazole 40 mg Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reducid 40 mg suspension | ৳ 50.00 | N/A |
Description
Overview of the medicine
Reducid 40 mg Suspension contains Esomeprazole, a proton pump inhibitor used to reduce acid production in the stomach. It is prescribed for conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For most conditions, 40 mg once daily. For Zollinger-Ellison syndrome, initial dose 40 mg twice daily, adjusted as needed.
Elderly
No dosage adjustment generally required based on age alone, but monitor for renal/hepatic impairment.
Renal_impairment
No dosage adjustment required.
How to Take
Take the suspension at least one hour before a meal. Shake well before use. Do not chew or crush.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell. This action blocks the final step in acid production, leading to a sustained decrease in gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 64% after a single 40 mg dose, increasing to 89% with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation
- Concurrent use with nelfinavir (due to significant drug interaction)
Drug Interactions
Digoxin
Increased digoxin exposure, monitor digoxin levels.
Warfarin
Increased INR and prothrombin time, monitor carefully.
Clopidogrel
Reduced antiplatelet effect, consider alternative PPIs or antiplatelet therapy.
Methotrexate
Increased methotrexate levels, monitor for toxicity.
Nelfinavir, Atazanavir
Reduced plasma concentrations, avoid co-administration.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset, drowsiness, tachycardia. No specific antidote. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk. Small amounts may be excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened), typically 28 days after reconstitution/opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Ongoing research continues to explore its long-term effects and new applications.
Lab Monitoring
- Monitor magnesium levels with prolonged use (especially with diuretics)
- Monitor INR/prothrombin time in patients on warfarin
- Liver function tests in patients with hepatic impairment
Doctor Notes
- Advise patients on lifestyle modifications to complement therapy.
- Review necessity of long-term PPI therapy periodically.
- Be aware of potential drug interactions, especially with antiplatelets and antivirals.
Patient Guidelines
- Take as directed by your doctor, preferably before a meal.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or visual disturbances. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid fatty, spicy, and acidic foods.
- Avoid alcohol and smoking.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce reflux symptoms.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.