Refain
Generic Name
Aceclofenac
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| refain 50 mg tablet | ৳ 0.83 | N/A |
Description
Overview of the medicine
Refain 50 mg Tablet contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), used for the relief of pain and inflammation in various musculoskeletal conditions.
Uses & Indications
Dosage
Adults
Typically, 50 mg twice daily, or as directed by the physician. The usual dose for aceclofenac is 100 mg twice daily, so 50mg might be used for dose titration or specific conditions.
Elderly
Lower doses may be considered for elderly patients, or as advised by a physician.
Renal_impairment
Caution required; dosage adjustment may be necessary in patients with mild to moderate renal impairment. Avoid in severe renal impairment.
How to Take
Administer orally. The tablet should be swallowed whole with sufficient liquid, preferably with or after food to minimize gastrointestinal discomfort.
Mechanism of Action
Aceclofenac inhibits prostaglandin synthesis by inhibiting the cyclooxygenase (COX) enzyme, primarily COX-2, reducing inflammation, pain, and fever.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes.
Excretion
Approximately two-thirds of the dose is excreted in the urine, mainly as conjugated metabolites, and one-third in the faeces.
Half life
Approximately 4-4.3 hours.
Absorption
Rapidly and completely absorbed after oral administration, peak plasma concentrations reached in 1.25 to 3 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes to 4'-hydroxyaceclofenac and other metabolites.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids, other NSAIDs
Increased risk of gastrointestinal side effects.
Lithium, Digoxin, Methotrexate
Increased plasma levels and toxicity.
Warfarin, other anticoagulants
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, occasionally convulsions. Management is primarily supportive and symptomatic, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Not recommended in the third trimester of pregnancy due to potential fetal harm. Use with caution in the first two trimesters only if clearly needed and benefits outweigh risks. Not recommended during breastfeeding as aceclofenac is excreted in small amounts in breast milk.
Side Effects
Contraindications
- Hypersensitivity to aceclofenac or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Corticosteroids, other NSAIDs
Increased risk of gastrointestinal side effects.
Lithium, Digoxin, Methotrexate
Increased plasma levels and toxicity.
Warfarin, other anticoagulants
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II receptor antagonists
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, rarely diarrhea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, occasionally convulsions. Management is primarily supportive and symptomatic, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Not recommended in the third trimester of pregnancy due to potential fetal harm. Use with caution in the first two trimesters only if clearly needed and benefits outweigh risks. Not recommended during breastfeeding as aceclofenac is excreted in small amounts in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities worldwide, including DGDA (Bangladesh)
Patent Status
Generic (Patent expired for Aceclofenac)
Clinical Trials
Extensive clinical trials have demonstrated Aceclofenac's efficacy and safety in various inflammatory and painful conditions. Ongoing post-marketing surveillance.
Lab Monitoring
- Complete blood count (CBC) periodically during long-term therapy
- Liver function tests (LFTs)
- Renal function tests (e.g., serum creatinine, BUN)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Consider gastroprotective agents for patients at high risk of GI complications.
- Monitor renal and hepatic function, and blood pressure, especially in elderly or at-risk patients on long-term therapy.
Patient Guidelines
- Take as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, persistent stomach pain, or dark stools immediately.
- Avoid lying down for at least 10 minutes after taking the tablet.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. If these occur, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in appropriate physical activity, as advised by your doctor.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
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