Reflacid
Generic Name
Magaldrate + Simethicone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reflacid 500 mg suspension | ৳ 150.00 | N/A |
Description
Overview of the medicine
Reflacid 500 mg Suspension is a combination medicine used to treat acidity, heartburn, and stomach ulcers. It contains Magaldrate, an antacid that neutralizes stomach acid, and Simethicone, an antiflatulent that reduces gas and bloating.
Uses & Indications
Dosage
Adults
10-20 mL (2-4 teaspoonfuls) four times daily, 20 minutes to 1 hour after meals and at bedtime, or as directed by physician.
Elderly
Same as adult dose, but caution in patients with renal impairment.
Renal_impairment
Use with caution. Avoid high doses and prolonged use due to potential accumulation of magnesium and aluminum.
How to Take
Shake well before use. Take orally, preferably after meals and at bedtime. Do not exceed recommended dose.
Mechanism of Action
Magaldrate reacts with gastric acid to form a neutral salt, reducing acidity. Simethicone works by reducing the surface tension of gas bubbles in the gastrointestinal tract, allowing them to coalesce and be expelled more easily.
Pharmacokinetics
Onset
Within 5-15 minutes (for antacid effect)
Excretion
Excreted in feces (Magaldrate as insoluble salts); Simethicone is excreted unchanged in feces.
Half life
Not applicable for Magaldrate (minimally absorbed); Simethicone is not absorbed.
Absorption
Magaldrate is minimally absorbed systemically. Simethicone is not absorbed from the gastrointestinal tract.
Metabolism
Not significantly metabolized systemically (Magaldrate); Simethicone is not metabolized.
Side Effects
Contraindications
- Hypersensitivity to Magaldrate, Simethicone, or any component of the formulation.
- Severe renal impairment (due to risk of magnesium and aluminum accumulation).
Drug Interactions
Digoxin
May decrease absorption of Digoxin.
Iron preparations
May reduce iron absorption.
Tetracyclines/Fluoroquinolones
Antacids can reduce the absorption of these antibiotics. Administer at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include diarrhea, abdominal pain, and constipation. In severe cases, especially with renal impairment, magnesium and aluminum toxicity may occur. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation, but consult a doctor before use, especially for prolonged periods or high doses.
Side Effects
Contraindications
- Hypersensitivity to Magaldrate, Simethicone, or any component of the formulation.
- Severe renal impairment (due to risk of magnesium and aluminum accumulation).
Drug Interactions
Digoxin
May decrease absorption of Digoxin.
Iron preparations
May reduce iron absorption.
Tetracyclines/Fluoroquinolones
Antacids can reduce the absorption of these antibiotics. Administer at least 2 hours apart.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include diarrhea, abdominal pain, and constipation. In severe cases, especially with renal impairment, magnesium and aluminum toxicity may occur. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation, but consult a doctor before use, especially for prolonged periods or high doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Well-established ingredients; extensive clinical data supports efficacy for acid reflux and gas symptoms. No recent major trials specifically for 'Reflacid' brand are typically highlighted.
Lab Monitoring
- Not typically required for short-term use. For prolonged use in patients with renal impairment, monitor serum magnesium and aluminum levels.
Doctor Notes
- Advise patients about potential drug interactions with other medications, particularly antibiotics and iron supplements.
- Caution in patients with chronic renal failure; monitor electrolyte levels if used long-term.
Patient Guidelines
- Shake the bottle well before each use.
- Do not take other medications within 1-2 hours of taking this suspension.
- Consult a doctor if symptoms persist for more than 2 weeks.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine generally does not affect the ability to drive or operate machinery.
Lifestyle Advice
- Avoid trigger foods like spicy, fatty, or acidic meals.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.