Reflon
Generic Name
Refloxacin 500 mg Tablet
Manufacturer
MediGen Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reflon 500 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Reflon 500 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria. Note: This is a hypothetical drug for demonstration purposes.
Uses & Indications
Dosage
Adults
500 mg once daily or 250 mg twice daily, depending on the severity and type of infection. Duration usually 7-14 days.
Elderly
No specific dose adjustment typically required, but monitor renal function.
Renal_impairment
Dose adjustment required for creatinine clearance < 50 mL/min (e.g., 250 mg once daily).
How to Take
Take Reflon 500 mg Tablet orally with a glass of water, with or without food. Do not crush or chew the tablet.
Mechanism of Action
Refloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily excreted renally (approximately 50-70% as unchanged drug) and some via feces.
Half life
Approximately 4-6 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.
Metabolism
Partially metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Refloxacin or other fluoroquinolones
- History of tendon disorders related to fluoroquinolone administration
- Children and adolescents (due to risk of arthropathy)
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
Increased risk of theophylline toxicity; monitor levels.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antacids (containing aluminum, magnesium, or calcium)
Can reduce Refloxacin absorption. Take Refloxacin 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management includes gastric lavage, activated charcoal, and symptomatic and supportive treatment. Maintain adequate hydration.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless essential, due to potential risks to fetal cartilage development and excretion into breast milk. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Refloxacin or other fluoroquinolones
- History of tendon disorders related to fluoroquinolone administration
- Children and adolescents (due to risk of arthropathy)
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
Increased risk of theophylline toxicity; monitor levels.
Corticosteroids
Increased risk of tendinopathy and tendon rupture.
Antacids (containing aluminum, magnesium, or calcium)
Can reduce Refloxacin absorption. Take Refloxacin 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management includes gastric lavage, activated charcoal, and symptomatic and supportive treatment. Maintain adequate hydration.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless essential, due to potential risks to fetal cartilage development and excretion into breast milk. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials demonstrated Reflon's efficacy and safety in treating various bacterial infections, showing comparable results to established fluoroquinolones. Further studies are ongoing for specific indications and resistant strains.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) periodically, especially in elderly or renally impaired patients.
- Prothrombin time/INR if co-administered with Warfarin.
Doctor Notes
- Caution in patients with epilepsy or predisposition to seizures.
- Monitor blood glucose levels in diabetic patients due to potential dysglycemia.
- Advise patients on the importance of hydration to prevent crystalluria.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Drink plenty of fluids to prevent crystalluria.
- Avoid excessive sun exposure and use sunscreen, as photosensitivity may occur.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Reflon may cause dizziness or lightheadedness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Balanced diet and adequate rest can aid recovery.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.