Rejoin-D
Generic Name
Glucosamine Sulfate + Chondroitin Sulfate + Vitamin D3
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rejoin d 750 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Rejoin-D 750 mg Tablet is a nutritional supplement primarily used to manage symptoms of osteoarthritis and other joint conditions. It contains Glucosamine Sulfate, Chondroitin Sulfate, and Vitamin D3, which are essential for cartilage formation, joint lubrication, and bone health.
Uses & Indications
Dosage
Adults
One tablet daily, preferably with a meal, or as directed by a physician. Treatment course typically lasts 6-12 weeks.
Elderly
No specific dose adjustment required for elderly patients, follow adult dosage.
Renal_impairment
Use with caution in severe renal impairment. Consult physician.
How to Take
Oral administration. Take the tablet whole with a glass of water, preferably with meals to minimize gastrointestinal upset.
Mechanism of Action
Glucosamine Sulfate stimulates the production of proteoglycans and collagen, essential components of cartilage matrix, thereby helping to rebuild and repair damaged cartilage. Chondroitin Sulfate provides structural components to cartilage, inhibits cartilage-degrading enzymes, and helps retain water, improving joint elasticity and shock absorption. Vitamin D3 helps in calcium absorption and bone mineralization, contributing to overall bone and joint health.
Pharmacokinetics
Onset
Symptomatic relief usually observed after 2-4 weeks of continuous use for Glucosamine/Chondroitin.
Excretion
Glucosamine: Primarily via urine and feces. Chondroitin: Primarily via urine. Vitamin D3: Metabolites excreted via bile and feces, small amount in urine.
Half life
Glucosamine: 15-17 hours. Chondroitin: Approximately 3-10 hours. Vitamin D3: ~24 hours (initial), metabolites have longer half-lives.
Absorption
Glucosamine: Approximately 90% is absorbed orally. Chondroitin: Low oral bioavailability, around 10-20%. Vitamin D3: Well absorbed orally, fat-soluble.
Metabolism
Glucosamine: Metabolized primarily in the liver, with some metabolism in the intestinal wall. Chondroitin: Partially depolymerized in the gut by bacteria. Vitamin D3: Metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] and then in the kidneys to 1,25-dihydroxyvitamin D [1,25(OH)2D], the active form.
Side Effects
Contraindications
- •Known hypersensitivity to Glucosamine, Chondroitin, Vitamin D3, or any component of the tablet.
- •Severe shellfish allergy (Glucosamine is often derived from shellfish).
- •Hypercalcemia or vitamin D toxicity (for Vitamin D3 component).
Drug Interactions
Thiazide diuretics
May increase the risk of hypercalcemia with Vitamin D3.
Tetracycline antibiotics
Glucosamine may decrease the absorption of tetracycline. Separate administration by several hours.
Warfarin (anticoagulant)
Glucosamine may enhance the effect of anticoagulants like warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Insulin and other antidiabetic agents
Glucosamine may affect glucose metabolism, potentially altering the effectiveness of antidiabetic drugs. Blood glucose monitoring is advisable.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose for Glucosamine/Chondroitin are generally mild (e.g., gastrointestinal upset). For Vitamin D3, excessive intake can lead to hypercalcemia. Management involves symptomatic and supportive care. Discontinue use and consult a physician.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data on safety. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drugstores, online retailers
Approval Status
Approved for sale as a dietary supplement.
Patent Status
No active patent for the combination.
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Global Brand Names
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