rejuven
Generic Name
N-Acetyl Cysteine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rejuven 500 mg tablet | ৳ 3.00 | N/A |
Description
Overview of the medicine
Rejuven-500 mg tablet contains N-Acetyl Cysteine (NAC), an antioxidant known for its role in glutathione production, liver protection, and respiratory health. It is used to reduce oxidative stress and as a mucolytic.
Uses & Indications
Dosage
Adults
For general antioxidant support: 500 mg once daily, or as directed by physician.
Elderly
No specific dose adjustment required, but caution with comorbidities and polypharmacy.
Renal_impairment
No specific dose adjustment for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take orally with or without food. If it's an effervescent tablet, dissolve completely in water before drinking.
Mechanism of Action
N-Acetyl Cysteine acts as a precursor to glutathione, a powerful antioxidant, by providing cysteine. It also exerts mucolytic action by breaking disulfide bonds in mucus, making it less viscous.
Pharmacokinetics
Onset
Mucolytic effect may be observed within 1 hour; antioxidant effects develop over time.
Excretion
Primarily renal as inorganic sulfate and conjugates.
Half life
Approximately 5.6 hours (total N-Acetyl Cysteine).
Absorption
Well absorbed orally, but bioavailability is low (4-10%) due to extensive first-pass metabolism.
Metabolism
Undergoes rapid deacetylation to cysteine and extensive first-pass metabolism in the liver.
Side Effects
Contraindications
- Hypersensitivity to N-Acetyl Cysteine or any component of the formulation
- Active peptic ulcer (for oral forms, due to potential irritation)
Drug Interactions
Nitroglycerin
May potentiate vasodilatory effects of nitroglycerin, leading to increased hypotension and headache.
Activated charcoal
May reduce NAC absorption if administered together. Separate administration by at least 2 hours.
Cough suppressants
Should not be used concomitantly, as they may hinder the expulsion of liquefied mucus.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Management includes supportive care and symptomatic treatment.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a doctor. While generally considered low risk, data specifically for 'Rejuven' is limited.
Side Effects
Contraindications
- Hypersensitivity to N-Acetyl Cysteine or any component of the formulation
- Active peptic ulcer (for oral forms, due to potential irritation)
Drug Interactions
Nitroglycerin
May potentiate vasodilatory effects of nitroglycerin, leading to increased hypotension and headache.
Activated charcoal
May reduce NAC absorption if administered together. Separate administration by at least 2 hours.
Cough suppressants
Should not be used concomitantly, as they may hinder the expulsion of liquefied mucus.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Management includes supportive care and symptomatic treatment.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a doctor. While generally considered low risk, data specifically for 'Rejuven' is limited.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Drugstores
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have supported the efficacy and safety of N-Acetyl Cysteine for its approved indications, including its role as a mucolytic and paracetamol antidote.
Lab Monitoring
- Liver function tests (especially in acetaminophen overdose management)
- Renal function tests (in patients with severe renal impairment)
- Blood gases (in severe respiratory conditions)
Doctor Notes
- Advise patients on adequate hydration, especially when using NAC for mucolytic purposes.
- Monitor patients for signs of hypersensitivity reactions, particularly with initial doses.
- When used for paracetamol overdose, ensure appropriate loading and maintenance doses are administered promptly.
Patient Guidelines
- Do not exceed the recommended dose without consulting a healthcare professional.
- Inform your doctor about all existing medical conditions and current medications.
- If you experience any severe side effects, seek immediate medical attention.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose to catch up.
Driving Precautions
Generally not expected to affect ability to drive or operate machinery. However, if dizziness or drowsiness occurs, avoid such activities until you feel well.
Lifestyle Advice
- Maintain a healthy diet rich in fruits and vegetables to further support antioxidant processes.
- Ensure adequate hydration, especially when used as a mucolytic, to help thin secretions.
- Avoid smoking and exposure to pollutants for better respiratory health.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.