Relaxen
Generic Name
Bromazepam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| relaxen 5 mg tablet | ৳ 0.68 | N/A |
Description
Overview of the medicine
Relaxen (Bromazepam) is a benzodiazepine derivative with anxiolytic, sedative, hypnotic, muscle relaxant, and anticonvulsant properties. It is primarily used to manage anxiety and tension.
Uses & Indications
Dosage
Adults
Typical oral dose for anxiety is 3-18 mg daily, in divided doses. For severe cases, up to 30 mg daily.
Elderly
Lower doses are recommended, typically half of the adult dose, starting with 1.5 mg daily in divided doses, due to increased sensitivity and slower metabolism.
Renal_impairment
Dose reduction may be necessary in patients with severe renal impairment. Careful monitoring is advised.
How to Take
Take orally with or without food. Do not chew or crush the tablet. Take exactly as prescribed by your doctor.
Mechanism of Action
Bromazepam enhances the effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, leading to central nervous system depression, which produces its anxiolytic, sedative, and muscle relaxant effects.
Pharmacokinetics
Onset
Anxiolytic effects typically within 30-60 minutes.
Excretion
Mainly excreted in urine as metabolites.
Half life
Approximately 10-20 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 1-2 hours.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (mainly CYP3A4) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to bromazepam or other benzodiazepines
- Myasthenia gravis
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Severe hepatic insufficiency
Drug Interactions
Alcohol
Potentiates sedative effects.
Opioids
Increased risk of sedation, respiratory depression, coma, and death.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase bromazepam levels.
Other CNS depressants (e.g., antidepressants, antipsychotics, antihistamines)
Additive CNS depressant effects.
Storage
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, lethargy, ataxia, dysarthria, and hypotension. Severe cases may lead to coma and respiratory depression. Management involves supportive care and gastric decontamination. Flumazenil may be used in severe cases.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the first trimester, due to potential risk of congenital malformations. Avoid during lactation as bromazepam passes into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
Clinical Trials
Numerous clinical trials have established the efficacy and safety of bromazepam for anxiety disorders. Further research often focuses on comparative efficacy and long-term effects.
Lab Monitoring
- Liver function tests (periodically during long-term therapy)
- Renal function tests (in patients with impairment)
Doctor Notes
- Prescribe for shortest effective duration.
- Warn patients about dependence and withdrawal.
- Counsel on avoiding alcohol and other CNS depressants.
- Monitor for signs of misuse or abuse.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor.
- Avoid alcohol during treatment.
- Be aware of the risk of dependence, especially with prolonged use.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness, dizziness, or impaired concentration. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Practice relaxation techniques.
- Maintain a regular sleep schedule.
- Avoid excessive caffeine.
- Engage in regular physical activity.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.