Relaxen
Generic Name
Diazepam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| relaxen 5 mg tablet | ৳ 0.68 | N/A |
Description
Overview of the medicine
Relaxen 5 mg Tablet contains Diazepam, a benzodiazepine, primarily used for anxiety, insomnia, muscle spasms, and seizures. It acts on the central nervous system to produce a calming effect.
Uses & Indications
Dosage
Adults
Anxiety: 2-10 mg, 2-4 times daily. Insomnia: 5-15 mg at bedtime. Muscle spasm: 2-10 mg, 3-4 times daily. Acute alcohol withdrawal: 10 mg 3-4 times during the first 24 hours, then 5 mg 3-4 times daily as needed.
Elderly
Initially 2-2.5 mg, once or twice daily, gradually increasing if needed.
Renal_impairment
No specific dose adjustment for mild to moderate impairment, but caution advised. Use lowest effective dose.
How to Take
Oral. Can be taken with or without food. Swallow the tablet whole with water.
Mechanism of Action
Diazepam enhances the effect of gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to sedative, anxiolytic, anticonvulsant, and muscle relaxant effects.
Pharmacokinetics
Onset
30-60 minutes (oral)
Excretion
Mainly excreted in urine as glucuronide conjugates of metabolites.
Half life
20-100 hours (for Diazepam and active metabolites)
Absorption
Well absorbed orally, peak plasma concentrations reached within 1-1.5 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2C19 and CYP3A4, to active metabolites like nordiazepam, temazepam, and oxazepam.
Side Effects
Contraindications
- •Acute narrow-angle glaucoma
- •Severe respiratory insufficiency
- •Severe hepatic insufficiency
- •Sleep apnea syndrome
- •Myasthenia gravis
- •Children under 6 months (except for status epilepticus)
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
Alcohol and other CNS depressants
Enhanced sedative effects.
CYP3A4/2C19 inducers (e.g., rifampicin, carbamazepine)
May decrease diazepam plasma levels.
CYP3A4/2C19 inhibitors (e.g., ketoconazole, fluvoxamine)
May increase diazepam plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, diminished reflexes, coma, and respiratory depression. Treatment involves supportive care, gastric lavage, and flumazenil (benzodiazepine antagonist) if severe.
Pregnancy & Lactation
Pregnancy Category D. Avoid during pregnancy, especially first trimester, due to risk of congenital malformations and neonatal withdrawal symptoms. Excreted in breast milk, avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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