Relitch
Generic Name
Esomeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| relitch 005 01 rectal ointment | ৳ 30.10 | N/A |
Description
Overview of the medicine
Relitch (Esomeprazole) is a proton pump inhibitor used to treat conditions caused by excess stomach acid, such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
20 mg or 40 mg once daily, depending on indication. For GERD: 20-40 mg once daily for 4-8 weeks.
Elderly
No specific dosage adjustment; use with caution.
Renal_impairment
No dosage adjustment needed.
How to Take
Take orally, at least one hour before a meal. Swallow the capsule/tablet whole; do not chew or crush.
Mechanism of Action
Esomeprazole selectively inhibits the H+/K+-ATPase (proton pump) in the secretory canaliculi of the gastric parietal cells, thereby blocking the final step of acid production.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Approximately 80% via urine and 20% via feces.
Half life
Approximately 1.5 hours.
Absorption
Rapidly absorbed, peak plasma concentrations occur within 1-2 hours. Bioavailability is approximately 64% (40 mg single dose) and 89% (repeated dose).
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to esomeprazole or any components of the formulation, or to other substituted benzimidazoles.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor for bleeding.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma concentrations of methotrexate, especially with high-dose use.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms are generally mild and reversible. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed during pregnancy. Excreted into breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in various clinical trials demonstrating efficacy and safety for approved indications, including healing of erosive esophagitis and maintenance of healing.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use), liver function tests in patients with hepatic impairment.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with the treatment goals.
- Re-evaluate the need for continued therapy periodically, especially for long-term use.
- Monitor for potential drug interactions and adverse effects, particularly hypomagnesemia.
Patient Guidelines
- Take as directed, do not chew or crush the capsule/tablet. Inform your doctor if symptoms persist or worsen. Do not stop treatment abruptly without consulting your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or visual disturbances; caution advised when driving or operating machinery.
Lifestyle Advice
- Avoid spicy, fatty foods, caffeine, and alcohol. Elevate the head of your bed for GERD symptoms. Maintain a healthy weight.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.