Orgovyx
Generic Name
Relugolix 120 mg Tablet
Manufacturer
Myovant Sciences/Sumitomo Pharma
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| relugoli 120 mg tablet | ৳ 250.00 | ৳ 2,500.00 |
Description
Overview of the medicine
Relugolix 120 mg tablet is an oral gonadotropin-releasing hormone (GnRH) receptor antagonist used for the treatment of adult patients with advanced prostate cancer.
Uses & Indications
Dosage
Adults
Initial loading dose of 360 mg (three 120 mg tablets) on the first day, followed by 120 mg (one 120 mg tablet) orally once daily.
Elderly
No dosage adjustment is required for elderly patients.
Renal_impairment
Mild to moderate renal impairment: No dosage adjustment. Severe renal impairment (eGFR 15-29 mL/min): Initial loading dose of 180 mg on Day 1, followed by 60 mg orally once daily. End-stage renal disease (eGFR <15 mL/min) or on hemodialysis: Avoid use.
How to Take
Take orally once daily, with or without food, at approximately the same time each day. Swallow the tablet whole.
Mechanism of Action
Relugolix competitively binds to and blocks GnRH receptors in the anterior pituitary gland, which reduces the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This leads to a rapid and sustained decrease in testosterone production by the testes.
Pharmacokinetics
Onset
Testosterone suppression to castration levels typically occurs within 4 days.
Excretion
Excreted predominantly via feces (approximately 81%), with minor renal excretion (approximately 4.2%).
Half life
Approximately 61 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations (Tmax) achieved in approximately 2 hours. Absolute bioavailability is approximately 12%.
Metabolism
Primarily metabolized by CYP3A and esterases.
Side Effects
Contraindications
- Known hypersensitivity to relugolix or any components of the tablet.
- Pregnancy (can cause fetal harm).
Drug Interactions
P-glycoprotein (P-gp) Inhibitors (e.g., cyclosporine, erythromycin, verapamil)
Avoid concomitant use. If unavoidable, reduce relugolix dose to 60 mg once daily after a 180 mg loading dose on Day 1.
P-glycoprotein (P-gp) Inducers (e.g., rifampin, carbamazepine, St. John's Wort)
Avoid concomitant use with strong P-gp inducers.
Storage
Store at room temperature (20°C to 25°C), with excursions permitted to 15°C to 30°C. Protect from moisture. Keep out of reach of children.
Overdose
No specific antidote for relugolix overdose. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Relugolix is contraindicated in pregnant women as it can cause fetal harm. Females of reproductive potential should use effective contraception during treatment and for 2 weeks after the last dose. It is unknown if relugolix is excreted in human milk, so breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date, as per manufacturer's specifications.
Availability
Available in countries where approved (e.g., US, Canada, Japan)
Approval Status
FDA Approved (e.g., US)
Patent Status
Patented
Clinical Trials
Relugolix was approved based on results from the HERO study, a Phase 3 randomized, open-label trial in men with advanced prostate cancer, demonstrating rapid, sustained testosterone suppression.
Lab Monitoring
- Liver function tests (ALT, AST)
- Lipid panel (triglycerides)
- Testosterone levels (to confirm castration)
- Electrolytes and ECG (if QTc prolongation risk factors present)
Doctor Notes
- Counsel patients on potential cardiovascular risks and bone health. Monitor LFTs and testosterone levels regularly. Advise on compliance and potential drug interactions, especially with P-gp inhibitors/inducers.
Patient Guidelines
- Take relugolix exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember on the same day. If it is not taken on the same day, skip the missed dose and take the next dose at the regularly scheduled time. Do not take two doses to make up for a missed dose.
Driving Precautions
Relugolix may cause fatigue. Patients should exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Maintain a healthy diet and engage in regular exercise as advised by your doctor.
- Manage cardiovascular risk factors.
- Report any new or worsening symptoms promptly.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.