Remacid
Generic Name
Cefuroxime Axetil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remacid 175 mg suspension | ৳ 32.50 | N/A |
Description
Overview of the medicine
Remacid 175 mg Suspension contains Cefuroxime Axetil, a second-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is effective against various Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
Typically 250 mg twice daily for most infections. For severe infections or certain conditions, dosage may be increased up to 500 mg twice daily. For uncomplicated gonorrhea, a single 1 gm dose.
Elderly
No specific dose adjustment is usually required unless severe renal impairment is present.
Renal_impairment
Dosage reduction may be necessary. For creatinine clearance 10-29 mL/min, 250 mg once daily. For <10 mL/min, 250 mg every 48 hours.
How to Take
Oral administration. Take with food to enhance absorption and reduce gastrointestinal upset. Shake the suspension well before use.
Mechanism of Action
Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final stage of bacterial cell wall synthesis. This leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Typically within 1 hour.
Excretion
Excreted unchanged in the urine, mainly via glomerular filtration and tubular secretion.
Half life
Approximately 1 to 1.5 hours.
Absorption
Well absorbed from the gastrointestinal tract and rapidly hydrolyzed to cefuroxime in the intestinal mucosa and blood. Absorption is enhanced by food.
Metabolism
Not extensively metabolized; primarily hydrolyzed to the active compound cefuroxime.
Side Effects
Contraindications
- Hypersensitivity to Cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reactions to any other type of beta-lactam antibacterial agent (e.g., penicillins)
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the plasma concentration versus time curve by about 50%, prolonging cefuroxime's activity.
Loop diuretics
Concurrent administration with potent loop diuretics (e.g., furosemide) may enhance nephrotoxicity, especially in patients with pre-existing renal impairment.
Oral contraceptives
May reduce the efficacy of oral contraceptives. Additional non-hormonal contraception is recommended.
Antacids/H2 blockers/Proton pump inhibitors
May reduce the bioavailability of cefuroxime axetil, especially due to a reduction in gastric acidity. Should be taken at least 1-2 hours apart.
Storage
Store dry powder below 30°C in a cool, dry place, away from light and moisture. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 10 days.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Management is primarily supportive. Hemodialysis and peritoneal dialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Cefuroxime crosses the placenta. Use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but caution is advised.
Side Effects
Contraindications
- Hypersensitivity to Cefuroxime, other cephalosporins, or any component of the formulation
- History of severe hypersensitivity reactions to any other type of beta-lactam antibacterial agent (e.g., penicillins)
Drug Interactions
Probenecid
Concomitant administration with probenecid increases the area under the plasma concentration versus time curve by about 50%, prolonging cefuroxime's activity.
Loop diuretics
Concurrent administration with potent loop diuretics (e.g., furosemide) may enhance nephrotoxicity, especially in patients with pre-existing renal impairment.
Oral contraceptives
May reduce the efficacy of oral contraceptives. Additional non-hormonal contraception is recommended.
Antacids/H2 blockers/Proton pump inhibitors
May reduce the bioavailability of cefuroxime axetil, especially due to a reduction in gastric acidity. Should be taken at least 1-2 hours apart.
Storage
Store dry powder below 30°C in a cool, dry place, away from light and moisture. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 10 days.
Overdose
Overdose symptoms may include cerebral irritation leading to convulsions. Management is primarily supportive. Hemodialysis and peritoneal dialysis can remove cefuroxime from the body.
Pregnancy & Lactation
Pregnancy Category B. Cefuroxime crosses the placenta. Use in pregnancy only if clearly needed. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
As per manufacturer's instructions, typically 2-3 years for dry powder. Reconstituted suspension is stable for 10 days when stored under refrigeration.
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired for original drug)
WHO Essential Medicine
YesClinical Trials
Cefuroxime Axetil has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across a wide range of bacterial infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Liver function tests (periodically, especially with long-term use)
- Complete blood count (rarely, in prolonged therapy)
Doctor Notes
- Educate patients on the importance of completing the full course to prevent resistance and recurrence.
- Advise patients to take with food to minimize GI upset and improve absorption.
- Monitor for signs of C. difficile infection if diarrhea becomes severe or persistent during or after treatment.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if you feel better.
- Do not share this medication with others.
- Shake the suspension well before each use.
- Store in the refrigerator (for reconstituted suspension) and discard after the recommended period.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated.
- Avoid alcohol consumption during treatment as it may worsen side effects.
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