Remdigen
Generic Name
Remdesivir
Manufacturer
Example Generic Manufacturer (e.g., Square Pharmaceuticals Ltd. for Bangladesh)
Country
Bangladesh (example)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remdigen 5 mg injection | ৳ 2,300.00 | N/A |
Description
Overview of the medicine
Remdigen (Remdesivir) is an antiviral medication used for the treatment of coronavirus disease 2019 (COVID-19) in adults and pediatric patients requiring hospitalization or at high risk of progression to severe COVID-19.
Uses & Indications
Dosage
Adults
A single loading dose of 200 mg on Day 1, followed by 100 mg once daily from Day 2 for 4-9 days via intravenous infusion. Total treatment duration is typically 5 to 10 days.
Elderly
No specific dose adjustment is required for elderly patients. Dosage is similar to adults.
Renal_impairment
Not recommended in patients with eGFR less than 30 mL/min due to accumulation of the sulfobutylether beta-cyclodextrin (SBECD) excipient. For patients with eGFR ≥ 30 mL/min, no dose adjustment is needed.
How to Take
Administer via intravenous infusion only. Must be diluted prior to infusion. The infusion time should be 30-120 minutes.
Mechanism of Action
Remdesivir is an adenosine nucleotide prodrug that metabolizes to its active form, remdesivir triphosphate. This active metabolite acts as a viral RNA-dependent RNA polymerase (RdRp) inhibitor, leading to delayed chain termination during viral RNA replication and inhibition of SARS-CoV-2.
Pharmacokinetics
Onset
Rapid due to intravenous administration.
Excretion
Primarily renal excretion of metabolites. Approximately 74% of the dose is excreted in urine and 18% in feces.
Half life
The parent drug has a short plasma half-life of approximately 1 hour. The active metabolite (GS-441524) has a half-life of approximately 20-25 hours.
Absorption
Administered intravenously, resulting in 100% bioavailability. Peak plasma concentrations of the active metabolite are observed rapidly after infusion.
Metabolism
Rapidly metabolized intracellularly to its active triphosphate form. The primary metabolic pathway involves hydrolysis of the ester moiety by host cathepsin A and carboxylesterase 1, followed by phosphorylation.
Side Effects
Contraindications
- Patients with a history of hypersensitivity reaction to Remdesivir or any components of the formulation.
Drug Interactions
Immunosuppressants
No significant pharmacokinetic interactions expected, but clinical significance to be evaluated.
Chloroquine or Hydroxychloroquine
Co-administration with chloroquine phosphate or hydroxychloroquine sulfate is not recommended as it may reduce the antiviral activity of Remdesivir.
Storage
Store unopened vials at room temperature (20°C to 25°C), protect from light. Reconstituted or diluted solutions must be used within specified timeframes (e.g., 24 hours at room temp or 48 hours refrigerated).
Overdose
There is no specific antidote for Remdesivir overdose. Management should consist of supportive treatment, including clinical monitoring and monitoring of laboratory parameters. Hemodialysis is generally not effective for removing Remdesivir.
Pregnancy & Lactation
Use during pregnancy is acceptable when the potential benefits outweigh the potential risks. Limited data are available regarding its presence in human milk, but benefits of breastfeeding should be considered along with potential risks.
Side Effects
Contraindications
- Patients with a history of hypersensitivity reaction to Remdesivir or any components of the formulation.
Drug Interactions
Immunosuppressants
No significant pharmacokinetic interactions expected, but clinical significance to be evaluated.
Chloroquine or Hydroxychloroquine
Co-administration with chloroquine phosphate or hydroxychloroquine sulfate is not recommended as it may reduce the antiviral activity of Remdesivir.
Storage
Store unopened vials at room temperature (20°C to 25°C), protect from light. Reconstituted or diluted solutions must be used within specified timeframes (e.g., 24 hours at room temp or 48 hours refrigerated).
Overdose
There is no specific antidote for Remdesivir overdose. Management should consist of supportive treatment, including clinical monitoring and monitoring of laboratory parameters. Hemodialysis is generally not effective for removing Remdesivir.
Pregnancy & Lactation
Use during pregnancy is acceptable when the potential benefits outweigh the potential risks. Limited data are available regarding its presence in human milk, but benefits of breastfeeding should be considered along with potential risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as per manufacturer's specifications. Once reconstituted/diluted, adhere to specific storage instructions.
Availability
Available in hospitals and pharmacies with a valid prescription.
Approval Status
Approved for Emergency Use Authorization (EUA) / Full Approval in many regions for COVID-19.
Patent Status
Patent protected (original manufacturer), but widely available as generics through compulsory licenses during the pandemic.
WHO Essential Medicine
YesClinical Trials
Supported by results from pivotal clinical trials such as ACTT-1 (Adaptive COVID-19 Treatment Trial) and Solidarity trial, which demonstrated its efficacy in reducing recovery time and improving clinical status in hospitalized COVID-19 patients.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) at baseline and daily during treatment.
- Renal function (eGFR, serum creatinine) at baseline and daily during treatment.
Doctor Notes
- Administer only in a hospital setting with appropriate monitoring capabilities.
- Monitor liver function tests (LFTs) and renal function (eGFR/creatinine) daily during treatment.
- Discontinue if transaminase elevations are >10 times the upper limit of normal or if patients develop signs/symptoms of liver inflammation with transaminase elevations >5 times the upper limit of normal.
- Not for use in patients with severe renal impairment (eGFR <30 mL/min) unless potential benefit outweighs risk, considering the SBECD excipient.
Patient Guidelines
- Report any unusual symptoms or adverse reactions to your healthcare provider immediately.
- Complete the full course of treatment as prescribed by your doctor.
- Remdigen must be administered by a healthcare professional in a clinical setting.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. Do not double the dose to make up for a missed dose. Consult the healthcare provider.
Driving Precautions
May cause dizziness or lightheadedness in some patients. Patients should be advised to avoid driving or operating machinery if they experience these effects.
Lifestyle Advice
- Maintain adequate hydration.
- Ensure sufficient rest during the treatment period.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.