Remicov
Generic Name
Remdesivir
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remicov 5 mg injection | ৳ 2,000.00 | N/A |
Description
Overview of the medicine
Remicov 5 mg Injection contains Remdesivir, an antiviral medication used for the treatment of COVID-19 in adults and pediatric patients requiring hospitalization. It is administered intravenously.
Uses & Indications
Dosage
Adults
Loading dose: 200 mg on Day 1, followed by 100 mg once daily from Day 2 for 4-9 days, for a total treatment duration of 5-10 days depending on clinical response.
Elderly
No specific dose adjustment required based on age.
Renal_impairment
Not recommended for patients with eGFR <30 mL/min due to potential accumulation of excipient sulfobutylether beta-cyclodextrin (SBECD).
How to Take
For intravenous infusion only. Must be reconstituted and diluted prior to administration. Administer over 30-120 minutes.
Mechanism of Action
Remdesivir is a prodrug that is metabolized intracellularly to its active nucleoside triphosphate metabolite. This metabolite acts as an adenosine triphosphate (ATP) analog, interfering with the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, leading to termination of viral RNA transcription and inhibition of viral replication.
Pharmacokinetics
Onset
Rapid, typically within hours of first dose.
Excretion
Mainly renal excretion of the active metabolite and other inactive metabolites. Small portion via feces.
Half life
Remdesivir: ~1 hour (parent drug). Active metabolite (GS-441524): ~20-25 hours (intracellular half-life).
Absorption
Administered intravenously, thus 100% bioavailability. Rapidly converted to its active metabolite.
Metabolism
Primarily metabolized to the active nucleoside triphosphate. Hydrolysis by esterases and phosphorylation by host kinases.
Side Effects
Contraindications
- •Hypersensitivity to remdesivir or any component of the formulation.
- •Patients with severe renal impairment (eGFR <30 mL/min) due to excipient accumulation risk.
Drug Interactions
Chloroquine/Hydroxychloroquine
Coadministration is not recommended as they may antagonize the intracellular metabolic activation and antiviral activity of remdesivir.
Storage
Store unopened vials below 30°C (86°F). Do not freeze. Protect from light. Reconstituted solution: Store at 2°C to 25°C for up to 24 hours.
Overdose
No specific antidote. Management involves supportive care, including monitoring of vital signs and clinical status. Hemodialysis is not effective at removing significant amounts of remdesivir.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit outweighs the potential risk to the fetus. Lactation: Weigh the benefits of breastfeeding against the potential risks of remdesivir to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months, when stored as recommended. Reconstituted solution should be used within 24 hours (if refrigerated) or 4 hours (at room temp).
Availability
Hospitals, Specialized clinics
Approval Status
Emergency Use Authorization (EUA) / Conditional Approval
Patent Status
Patented by Gilead Sciences (generic versions available under licensing)
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Global Brand Names
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