Remivir
Generic Name
Remivir-5-mg-injection
Manufacturer
Global Pharma Ltd.
Country
USA
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remivir 5 mg injection | ৳ 2,000.00 | N/A |
Description
Overview of the medicine
Remivir 5 mg Injection is an antiviral medication used to treat certain severe viral infections. It works by inhibiting viral replication, thereby reducing the viral load in the body.
Uses & Indications
Dosage
Adults
5 mg/kg IV once daily for 7-10 days, infused over 30-60 minutes.
Elderly
No specific dose adjustment needed unless renal function is impaired.
Renal_impairment
Reduce dose to 2.5 mg/kg IV once daily for CrCl 30-50 mL/min; contraindicated if CrCl <30 mL/min.
How to Take
Administer intravenously after reconstitution. The solution should be clear and colorless. Do not administer as a rapid bolus injection.
Mechanism of Action
Remivir is a prodrug that is intracellularly phosphorylated to its active triphosphate form. This active metabolite competes with natural nucleoside triphosphates for incorporation into viral DNA/RNA by viral reverse transcriptase, leading to chain termination and inhibition of viral replication.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Primarily excreted renally (approximately 70-80% as unchanged drug and metabolites)
Half life
Approximately 3-5 hours (active metabolite 18-24 hours)
Absorption
Rapidly absorbed after intravenous administration; bioavailability is 100%. Peak plasma concentrations achieved within 1 hour.
Metabolism
Primarily metabolized intracellularly by kinases to its active triphosphate form. Minimal hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Remivir or any component of the formulation
- Severe renal impairment (CrCl <30 mL/min)
Drug Interactions
NSAIDs
May increase Remivir plasma levels and nephrotoxicity.
Amphotericin B
Increased risk of nephrotoxicity.
Storage
Store unreconstituted powder at 2°C to 8°C (36°F to 46°F). Protect from light. Reconstituted solution stable for 24 hours at room temperature.
Overdose
Symptoms include severe nephrotoxicity, hepatotoxicity, and bone marrow suppression. Treatment is supportive; hemodialysis may be considered for severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if Remivir is excreted in human milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to Remivir or any component of the formulation
- Severe renal impairment (CrCl <30 mL/min)
Drug Interactions
NSAIDs
May increase Remivir plasma levels and nephrotoxicity.
Amphotericin B
Increased risk of nephrotoxicity.
Storage
Store unreconstituted powder at 2°C to 8°C (36°F to 46°F). Protect from light. Reconstituted solution stable for 24 hours at room temperature.
Overdose
Symptoms include severe nephrotoxicity, hepatotoxicity, and bone marrow suppression. Treatment is supportive; hemodialysis may be considered for severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. It is unknown if Remivir is excreted in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Hospitals, pharmacies, specialized clinics
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Patent protected (expires 2035)
WHO Essential Medicine
YesClinical Trials
Phase III trials demonstrated significant reduction in viral load and improved patient outcomes in severe viral pneumonia. Ongoing post-marketing surveillance for long-term safety.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC)
- Serum lactate levels
Doctor Notes
- Ensure adequate hydration before and during administration.
- Monitor renal function, liver enzymes, and CBC closely.
- Educate patients on potential signs of nephrotoxicity and lactic acidosis.
Patient Guidelines
- Report any signs of kidney problems or severe stomach pain immediately.
- Maintain adequate hydration during treatment.
- Do not stop treatment abruptly without consulting your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue. Advise caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption during treatment.
- Maintain a balanced diet.
- Inform your doctor about all other medications you are taking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.