Remylin
Generic Name
Methylcobalamin
Manufacturer
ACI Limited
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| remylin 500 mcg tablet | ৳ 4.50 | ৳ 45.00 |
Description
Overview of the medicine
Methylcobalamin is an active form of Vitamin B12, essential for nerve cell growth, blood formation, and DNA synthesis. It is used to treat vitamin B12 deficiency and various forms of neuropathy.
Uses & Indications
Dosage
Adults
Usually 500 mcg to 1500 mcg orally per day, divided into 1-3 doses, or as directed by a physician.
Elderly
No specific dosage adjustment is generally required for elderly patients, unless significant renal impairment is present.
Renal_impairment
No specific dosage adjustment for mild to moderate renal impairment. For severe impairment, consultation with a physician is recommended.
How to Take
Take the tablet orally with water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Methylcobalamin acts as a coenzyme in two critical metabolic reactions: the conversion of homocysteine to methionine (essential for maintaining myelin sheath and neuronal health) and the conversion of methylmalonyl-CoA to succinyl-CoA (involved in fatty acid and amino acid metabolism).
Pharmacokinetics
Onset
Clinical effects, especially for neurological symptoms, may take several weeks to months to become apparent.
Excretion
Excreted primarily via the bile, with some renal excretion of unmetabolized methylcobalamin.
Half life
Methylcobalamin has a relatively long half-life due to extensive storage in the liver and other tissues, typically several days to weeks.
Absorption
Readily absorbed from the gastrointestinal tract, especially when taken orally in therapeutic doses. Absorption involves intrinsic factor for larger doses but can also occur via passive diffusion.
Metabolism
Undergoes minimal metabolism; it is primarily converted into other cobalamin forms or excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to Methylcobalamin or any component of the formulation
- •Leber's disease (hereditary optic neuropathy) due to risk of exacerbating optic nerve atrophy
Drug Interactions
Metformin
Can decrease Vitamin B12 absorption with prolonged use.
Colchicine
May interfere with B12 absorption.
Chloramphenicol
May antagonize the hematologic response to B12 in anemic patients.
H2 Blockers (e.g., Ranitidine)
Similar to PPIs, may reduce B12 absorption.
Proton Pump Inhibitors (e.g., Omeprazole)
May reduce the absorption of Vitamin B12.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Methylcobalamin is a water-soluble vitamin, and overdose is highly unlikely to cause toxicity. Excess amounts are usually excreted via urine. No specific antidote is required; symptomatic and supportive measures may be used if necessary.
Pregnancy & Lactation
Methylcobalamin is generally considered safe during pregnancy and lactation when taken at recommended doses, as Vitamin B12 is essential for fetal development and infant health. However, consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities like DGDA
Patent Status
Generic drug, no active patent for the molecule
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in