Renapine-XR
Generic Name
Renapine extended-release tablet
Manufacturer
PharmaInnovate Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renapine xr 300 mg tablet | ৳ 22.00 | ৳ 132.00 |
Description
Overview of the medicine
Renapine-XR 300 mg is an extended-release atypical antipsychotic medication used for the treatment of schizophrenia and bipolar disorder. Its extended-release formulation allows for once-daily dosing, providing consistent medication levels throughout the day.
Uses & Indications
Dosage
Adults
Initial dose: 100 mg once daily, titrated up to 300 mg once daily based on clinical response and tolerability. Maximum recommended dose: 600 mg/day.
Elderly
Lower initial doses (e.g., 50 mg once daily) are recommended, with slower titration and careful monitoring.
Renal_impairment
No dose adjustment is typically required for mild to moderate renal impairment. For severe impairment, caution and dose reduction may be necessary.
How to Take
Take Renapine-XR tablets orally once daily, preferably in the evening, with or without food. Tablets should be swallowed whole and not chewed, crushed, or split.
Mechanism of Action
Renapine-XR is believed to exert its therapeutic effects through a combination of dopamine D2 and serotonin 5-HT2A receptor antagonism. It may also have activity at other receptors, including adrenergic alpha-1 and histamine H1 receptors, contributing to its overall pharmacological profile.
Pharmacokinetics
Onset
Clinical effects may be noticeable within a few days, but full therapeutic effect may take several weeks.
Excretion
Mainly excreted via urine (60%) and feces (30%) as metabolites, with a small percentage as unchanged drug.
Half life
Approximately 18-24 hours, supporting once-daily dosing.
Absorption
Well absorbed after oral administration. Peak plasma concentrations are reached within 4-8 hours. The extended-release formulation provides sustained release over 24 hours.
Metabolism
Primarily metabolized in the liver, largely by cytochrome P450 (CYP) enzymes, particularly CYP3A4 and CYP2D6.
Side Effects
Contraindications
- Known hypersensitivity to Renapine or any excipients in the formulation
- Severe central nervous system (CNS) depression
- Comatose states
Drug Interactions
Drugs that prolong QT interval
Potential for additive QT prolongation; use with caution.
CYP3A4 Inducers (e.g., Carbamazepine, Rifampin)
May decrease Renapine plasma concentrations, requiring dose increase of Renapine.
CNS Depressants (e.g., Alcohol, Benzodiazepines)
Increased risk of additive CNS depression and sedation.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase Renapine plasma concentrations, requiring dose reduction of Renapine.
Storage
Store at room temperature (20°C to 25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, hypotension, and extrapyramidal symptoms. Management is primarily supportive, including maintaining an adequate airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered. Continuous cardiovascular monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Renapine is excreted in human milk; caution should be exercised when Renapine-XR is administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to Renapine or any excipients in the formulation
- Severe central nervous system (CNS) depression
- Comatose states
Drug Interactions
Drugs that prolong QT interval
Potential for additive QT prolongation; use with caution.
CYP3A4 Inducers (e.g., Carbamazepine, Rifampin)
May decrease Renapine plasma concentrations, requiring dose increase of Renapine.
CNS Depressants (e.g., Alcohol, Benzodiazepines)
Increased risk of additive CNS depression and sedation.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase Renapine plasma concentrations, requiring dose reduction of Renapine.
Storage
Store at room temperature (20°C to 25°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, hypotension, and extrapyramidal symptoms. Management is primarily supportive, including maintaining an adequate airway, oxygenation, and ventilation. Gastric lavage and activated charcoal may be considered. Continuous cardiovascular monitoring is recommended.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Renapine is excreted in human milk; caution should be exercised when Renapine-XR is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory authorities
Patent Status
Under patent protection
Clinical Trials
Renapine-XR has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile for the approved indications. Post-marketing surveillance is ongoing.
Lab Monitoring
- Complete Blood Count (CBC) with differential
- Liver Function Tests (LFTs)
- Renal Function Tests
- Fasting Plasma Glucose
- Lipid Profile (cholesterol, triglycerides)
- ECG (prior to and periodically during treatment)
Doctor Notes
- Assess baseline metabolic parameters (weight, glucose, lipids) before starting treatment and monitor regularly.
- Educate patients on the importance of adherence and potential side effects, including the risk of NMS and TD.
- Consider dose adjustments in patients taking strong CYP3A4 inhibitors or inducers.
- Closely monitor elderly patients, especially those with dementia, due to increased mortality risk.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Do not stop taking Renapine-XR suddenly without consulting your doctor, as this may lead to withdrawal symptoms.
- Report any unusual side effects, especially severe muscle stiffness, fever, or uncontrolled movements.
- Avoid alcohol and other CNS depressants while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Renapine-XR may cause drowsiness, dizziness, or blurred vision, which could impair your ability to drive or operate machinery. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Renapine-XR therapy does not affect them adversely.
Lifestyle Advice
- Maintain a healthy diet and engage in regular physical activity to help manage potential weight gain and metabolic changes.
- Stay hydrated and avoid overheating, especially in hot weather, as antipsychotics can affect body temperature regulation.
- Avoid driving or operating heavy machinery until you know how this medication affects you.
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