Renibex
Generic Name
Renib
Manufacturer
MedVision Pharmaceuticals
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renib 40 mg tablet | ৳ 510.00 | ৳ 5,100.00 |
Description
Overview of the medicine
Renib is a selective Janus Kinase (JAK) inhibitor used for the treatment of various inflammatory and autoimmune conditions, such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Uses & Indications
Dosage
Adults
40 mg once daily, with or without food.
Elderly
No dosage adjustment generally required, but monitor renal and hepatic function carefully.
Renal_impairment
Dose adjustment may be necessary in moderate to severe renal impairment. In severe impairment, consider 20 mg once daily.
How to Take
Take the tablet orally, with or without food. Do not chew, crush, or break the tablet.
Mechanism of Action
Renib inhibits the activity of Janus Kinase (JAK) enzymes (primarily JAK1 and JAK3), which are involved in the signaling pathways of various pro-inflammatory cytokines. By blocking these pathways, Renib modulates the immune response and reduces inflammation.
Pharmacokinetics
Onset
Clinical efficacy typically observed within 2-4 weeks of initiation.
Excretion
Approximately 76% excreted via urine and 20% via feces.
Half life
Approximately 4-6 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations within 1-2 hours. Food does not significantly affect absorption.
Metabolism
Primarily metabolized by cytochrome P450 3A4 (CYP3A4) enzymes in the liver.
Side Effects
Contraindications
- Active serious infections
- Severe hepatic impairment
- Hypersensitivity to Renib or any excipients
- Active tuberculosis
Drug Interactions
Strong CYP3A4 inducers (e.g., Rifampicin)
May decrease Renib concentrations, potentially reducing efficacy.
Other immunosuppressants (e.g., Cyclosporine)
Increased risk of serious infections and other adverse reactions.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May increase Renib concentrations, requiring dose reduction.
Storage
Store below 25°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for Renib overdose. In case of overdose, provide symptomatic and supportive care. Hemodialysis may be considered if necessary.
Pregnancy & Lactation
Renib is not recommended during pregnancy due to potential fetal harm. For lactating mothers, a decision must be made whether to discontinue breastfeeding or discontinue the drug, considering the potential risk to the infant.
Side Effects
Contraindications
- Active serious infections
- Severe hepatic impairment
- Hypersensitivity to Renib or any excipients
- Active tuberculosis
Drug Interactions
Strong CYP3A4 inducers (e.g., Rifampicin)
May decrease Renib concentrations, potentially reducing efficacy.
Other immunosuppressants (e.g., Cyclosporine)
Increased risk of serious infections and other adverse reactions.
Strong CYP3A4 inhibitors (e.g., Ketoconazole)
May increase Renib concentrations, requiring dose reduction.
Storage
Store below 25°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for Renib overdose. In case of overdose, provide symptomatic and supportive care. Hemodialysis may be considered if necessary.
Pregnancy & Lactation
Renib is not recommended during pregnancy due to potential fetal harm. For lactating mothers, a decision must be made whether to discontinue breastfeeding or discontinue the drug, considering the potential risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Under patent
Clinical Trials
Multiple Phase 2 and Phase 3 clinical trials have been completed to evaluate the efficacy and safety of Renib in its approved indications.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Lipid Profile
- Creatinine
Doctor Notes
- Screen patients for infections before and during Renib therapy.
- Avoid live vaccinations prior to initiating Renib.
- Regular laboratory monitoring is crucial during Renib therapy.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- Report any unusual symptoms or signs of infection to your doctor immediately.
- Avoid live vaccinations while on Renib therapy.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.
Driving Precautions
Renib does not typically impair the ability to drive or operate heavy machinery. However, if you experience dizziness or any other side effects that might affect your concentration, avoid such activities.
Lifestyle Advice
- Maintain a healthy lifestyle and ensure adequate rest.
- Practice good hygiene to minimize the risk of infections.
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Global Brand Names
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