Renosart-Plus
Generic Name
Losartan Potassium 50 mg + Hydrochlorothiazide 12.5 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| renosart plus 50 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Renosart-Plus 50 mg Tablet is a combination medicine containing Losartan and Hydrochlorothiazide, used to treat high blood pressure (hypertension). It helps to lower blood pressure by relaxing blood vessels and increasing the excretion of excess water and salts from the body.
Uses & Indications
Dosage
Adults
The usual starting dose is one Renosart-Plus 50 mg tablet once daily. The maximum dose is typically Losartan 100 mg / Hydrochlorothiazide 25 mg once daily.
Elderly
No initial dosage adjustment is generally required for elderly patients, but renal function should be monitored.
Renal_impairment
Not recommended in patients with severe renal impairment (creatinine clearance <30 mL/min) or anuria. For moderate impairment, careful monitoring is advised.
How to Take
Take the tablet orally once daily, with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Losartan is an Angiotensin II Receptor Blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide is a thiazide diuretic that inhibits the reabsorption of sodium and chloride in the distal convoluted tubule, leading to increased excretion of sodium, chloride, and water, thereby reducing blood volume and blood pressure.
Pharmacokinetics
Onset
Onset of antihypertensive effect for Losartan is within 1-2 hours; for Hydrochlorothiazide, it is about 2 hours.
Excretion
Losartan and its active metabolite are excreted via urine and feces. Hydrochlorothiazide is primarily excreted unchanged in the urine.
Half life
Losartan has a half-life of about 2 hours, and its active metabolite (E-3174) has a half-life of 6-9 hours. Hydrochlorothiazide has a half-life of 5.6-15 hours.
Absorption
Losartan is well absorbed from the gastrointestinal tract, with an oral bioavailability of about 33%. Hydrochlorothiazide is also well absorbed from the GI tract, with a bioavailability of 65-75%.
Metabolism
Losartan undergoes significant first-pass metabolism by CYP2C9 and CYP3A4 to an active carboxylic acid metabolite (E-3174) and several inactive metabolites. Hydrochlorothiazide is not metabolized.
Side Effects
Contraindications
- •Hypersensitivity to Losartan, Hydrochlorothiazide, or sulfonamide-derived drugs.
- •Anuria.
- •Pregnancy (second and third trimesters).
- •Concomitant use with aliskiren in patients with diabetes or renal impairment.
Drug Interactions
Lithium
May increase serum lithium concentrations and lead to lithium toxicity.
Other antihypertensive agents
Additive effects may occur.
Alcohol, barbiturates, or narcotics
May potentiate orthostatic hypotension.
Non-steroidal anti-inflammatory drugs (NSAIDs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include hypotension, dizziness, palpitation, and electrolyte disturbances (e.g., hypokalemia, hyponatremia). Treatment is symptomatic and supportive, including correction of fluid and electrolyte imbalances. Hemodialysis is not effective for Losartan but may remove HCTZ.
Pregnancy & Lactation
Losartan/Hydrochlorothiazide is contraindicated during the second and third trimesters of pregnancy due to risk of fetal harm. It is not recommended during breastfeeding as both components may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA/FDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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