Replivir
Generic Name
Fictional Antiviral Compound 1 mg Tablet
Manufacturer
Fictional Pharma Inc.
Country
Global (Manufactured in Bangladesh)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| replivir 1 mg tablet | ৳ 90.00 | ৳ 900.00 |
Description
Overview of the medicine
Replivir 1 mg Tablet is an antiviral medication used to treat certain chronic viral infections by inhibiting the replication of the virus. It belongs to the class of nucleoside reverse transcriptase inhibitors.
Uses & Indications
Dosage
Adults
The usual recommended dose is 1 mg once daily, taken with or without food. Dosage may be adjusted based on viral load and renal function.
Elderly
No specific dose adjustment is required for elderly patients, but renal function should be monitored.
Renal_impairment
For patients with creatinine clearance <50 mL/min, the dose should be reduced or frequency altered (e.g., 1 mg every 48 hours) as per physician's advice.
How to Take
Take the tablet orally with a glass of water, with or without food. Do not crush, chew, or break the tablet. It should be taken at approximately the same time each day.
Mechanism of Action
Replivir acts as a nucleoside analog that gets incorporated into the viral DNA chain by reverse transcriptase, leading to chain termination and inhibition of viral DNA synthesis. This prevents the virus from replicating effectively.
Pharmacokinetics
Onset
Antiviral effects typically observed within 2-4 hours of initial dose, with steady-state concentrations achieved within 3-5 days of regular dosing.
Excretion
Mainly excreted renally as unchanged drug and its metabolites. Approximately 60-70% of the dose is excreted in urine within 24 hours.
Half life
Plasma elimination half-life is approximately 8-12 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1-2 hours after oral administration. Bioavailability is approximately 70-85%.
Metabolism
Primarily metabolized in the liver via phosphorylation to its active triphosphate form. Minor metabolism by CYP enzymes.
Side Effects
Contraindications
- Hypersensitivity to replivir or any component of the formulation.
- Severe pre-existing renal impairment without dose adjustment.
Drug Interactions
Ribavirin
May reduce the antiviral effect of replivir.
Didanosine
Increased risk of pancreatitis and peripheral neuropathy.
Nephrotoxic agents
Concurrent use may increase the risk of renal adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, monitor the patient for signs of toxicity (e.g., severe nausea, vomiting, lactic acidosis). Treatment is supportive. Hemodialysis may be beneficial in removing the drug.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether replivir is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to replivir or any component of the formulation.
- Severe pre-existing renal impairment without dose adjustment.
Drug Interactions
Ribavirin
May reduce the antiviral effect of replivir.
Didanosine
Increased risk of pancreatitis and peripheral neuropathy.
Nephrotoxic agents
Concurrent use may increase the risk of renal adverse effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, monitor the patient for signs of toxicity (e.g., severe nausea, vomiting, lactic acidosis). Treatment is supportive. Hemodialysis may be beneficial in removing the drug.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether replivir is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Globally available in pharmacies and hospitals
Approval Status
Hypothetically Approved by Regulatory Bodies
Patent Status
Patent Pending
WHO Essential Medicine
YesClinical Trials
Extensive Phase I, II, and III clinical trials demonstrated Replivir's efficacy and safety profile. Post-marketing surveillance continues to monitor long-term effects.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) at baseline and periodically during treatment.
- Renal function tests (serum creatinine, BUN, creatinine clearance) at baseline and periodically.
- Complete blood count (CBC) to monitor for hematological abnormalities.
- Viral load (HBV DNA or HIV RNA) monitoring to assess treatment efficacy.
Doctor Notes
- Ensure baseline liver and renal function tests are performed before initiating Replivir.
- Educate patients on the importance of adherence to avoid drug resistance.
- Monitor for signs of lactic acidosis, especially in patients with risk factors.
Patient Guidelines
- Take Replivir exactly as prescribed by your doctor.
- Do not stop taking Replivir without consulting your doctor, as this may lead to worsening of your condition.
- Report any unusual symptoms or side effects to your doctor immediately.
- Regular follow-up appointments and lab tests are crucial during treatment.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Replivir may cause dizziness or fatigue in some patients. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Avoid alcohol consumption during treatment, especially if liver function is compromised.
- Practice safe sex to prevent transmission of viral infections.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Replivir Brand
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