Repopain
Generic Name
Tizanidine Hydrochloride
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| repopain 10 mg tablet | ৳ 10.03 | ৳ 100.30 |
Description
Overview of the medicine
Repopain 10 mg Tablet contains Tizanidine Hydrochloride, a centrally acting skeletal muscle relaxant used to manage spasticity associated with multiple sclerosis, spinal cord injury, or other neurological conditions. It works by blocking nerve impulses that are sent from the brain to the muscles, thereby helping to relax the muscles and relieve pain.
Uses & Indications
Dosage
Adults
Initial dose 2 mg orally once daily, gradually increased to an optimal dose, typically 2-4 mg three times daily. Max 36 mg/day.
Elderly
Start with a lower dose (e.g., 2 mg once daily) and titrate slowly due to potential for increased sensitivity.
Renal_impairment
Reduce dose in patients with creatinine clearance <25 mL/min; initial dose 2 mg once daily, titrate slowly.
How to Take
Repopain 10 mg tablet should be taken orally. It can be taken with or without food, but consistency in administration with respect to food is recommended. Do not crush, chew, or break the tablet.
Mechanism of Action
Tizanidine is an alpha-2 adrenergic agonist. It acts by increasing presynaptic inhibition of motor neurons at the alpha-2 adrenergic receptors in the spinal cord, leading to a reduction in muscle tone. This reduces spasticity and muscle spasms.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly excreted by the kidneys (approximately 60% in urine as metabolites, 20% unchanged).
Half life
Approximately 2.5 hours
Absorption
Rapidly absorbed, with peak plasma concentrations occurring 1-2 hours post-dose. Bioavailability is about 40%.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 1A2 (CYP1A2) isoenzyme.
Side Effects
Contraindications
- Hypersensitivity to Tizanidine or any component of the formulation
- Concomitant use with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- Severe hepatic impairment
Drug Interactions
Alcohol
May increase CNS depressant effects and hypotension.
Oral contraceptives
May increase tizanidine exposure by reducing its clearance.
Fluvoxamine, Ciprofloxacin
Significant increase in tizanidine levels, leading to severe hypotension and CNS depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, bradycardia, hypotension, and respiratory depression. Treatment is symptomatic and supportive, including gastric lavage and supportive care for vital functions.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Excretion into breast milk is unknown; caution is advised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Tizanidine or any component of the formulation
- Concomitant use with strong CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- Severe hepatic impairment
Drug Interactions
Alcohol
May increase CNS depressant effects and hypotension.
Oral contraceptives
May increase tizanidine exposure by reducing its clearance.
Fluvoxamine, Ciprofloxacin
Significant increase in tizanidine levels, leading to severe hypotension and CNS depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, bradycardia, hypotension, and respiratory depression. Treatment is symptomatic and supportive, including gastric lavage and supportive care for vital functions.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Excretion into breast milk is unknown; caution is advised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Clinical trials have shown Tizanidine to be effective in reducing muscle tone and spasticity with a favorable safety profile when used as directed.
Lab Monitoring
- Liver function tests (baseline and periodically, especially in patients on higher doses or with risk factors)
- Blood pressure monitoring
Doctor Notes
- Counsel patients on the risk of orthostatic hypotension and CNS depression.
- Emphasize the importance of gradual dose titration and avoiding abrupt discontinuation.
- Monitor liver function tests, especially with doses above 20-24 mg/day or in patients with hepatic impairment.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medication abruptly without consulting your doctor, as it can lead to rebound spasticity or hypertension.
- Avoid alcohol while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medication may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Avoid activities requiring mental alertness (e.g., driving, operating machinery) until you know how this medicine affects you. Stay hydrated.
- Report any signs of liver problems (e.g., dark urine, persistent nausea, yellowing skin/eyes) to your doctor immediately.
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Global Brand Names
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