Repotyn-Max
Generic Name
Epoetin Alfa (Recombinant human erythropoietin)
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| repotyn max 7 10 injection | ৳ 401.20 | N/A |
Description
Overview of the medicine
Repotyn-Max 7-10 Injection contains Epoetin Alfa, a recombinant human erythropoietin. It stimulates red blood cell production and is used to treat anemia associated with chronic kidney disease, chemotherapy, and certain other conditions.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on indication, route (IV/SC), and patient response. Typically initiated at 50-150 IU/kg three times a week or once weekly, then adjusted to maintain target hemoglobin levels (e.g., 10-12 g/dL).
Elderly
No specific dose adjustment required based on age alone, but monitoring for adverse effects is crucial.
Renal_impairment
Dosage is adjusted based on hemoglobin response and target levels for CKD patients. No specific adjustment for mild to moderate impairment beyond standard CKD dosing.
How to Take
Administered by subcutaneous or intravenous injection. IV administration is preferred for dialysis patients. SC administration is suitable for non-dialysis CKD patients and others. Do not shake. Inspect visually for particulate matter or discoloration before administration.
Mechanism of Action
Epoetin alfa stimulates erythropoiesis by binding to the erythropoietin receptor on erythroid progenitor cells, leading to their proliferation and differentiation into mature red blood cells.
Pharmacokinetics
Onset
Increased reticulocytes within 7-10 days, significant rise in hemoglobin within 2-6 weeks.
Excretion
Minimal renal excretion of intact epoetin alfa.
Half life
Intravenous: approximately 4-13 hours. Subcutaneous: 18-36 hours.
Absorption
Administered subcutaneously or intravenously. Subcutaneous absorption is slower and more prolonged.
Metabolism
Primarily cleared by erythroid progenitor cells and the reticuloendothelial system. Minimal hepatic metabolism.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure Red Cell Aplasia (PRCA) unrelated to iron deficiency.
- Known hypersensitivity to epoetin alfa, albumin, or any component of the formulation.
Drug Interactions
Cyclosporine
May require dose adjustment of cyclosporine due to increased clearance.
Iron supplements
Essential for optimal response; inadequate iron stores can limit effectiveness.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdosage can lead to polycythemia (excessive red blood cells) which increases blood viscosity and risk of thromboembolic events. Treatment involves phlebotomy to reduce hematocrit.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Epoetin Alfa is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Uncontrolled hypertension.
- Pure Red Cell Aplasia (PRCA) unrelated to iron deficiency.
- Known hypersensitivity to epoetin alfa, albumin, or any component of the formulation.
Drug Interactions
Cyclosporine
May require dose adjustment of cyclosporine due to increased clearance.
Iron supplements
Essential for optimal response; inadequate iron stores can limit effectiveness.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Do not shake.
Overdose
Overdosage can lead to polycythemia (excessive red blood cells) which increases blood viscosity and risk of thromboembolic events. Treatment involves phlebotomy to reduce hematocrit.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is unknown if Epoetin Alfa is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months when stored correctly.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various anemia indications.
Lab Monitoring
- Hemoglobin and hematocrit levels (at least weekly initially, then less frequently).
- Iron status (ferritin, transferrin saturation) before and during treatment.
- Blood pressure monitoring.
Doctor Notes
- Emphasize the importance of maintaining target hemoglobin levels to avoid cardiovascular risks.
- Regularly assess iron status and provide iron supplementation as needed.
Patient Guidelines
- Do not miss scheduled doses.
- Report any unusual side effects, especially signs of blood clots or allergic reactions.
- Ensure adequate iron intake as advised by your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or seizures in some patients; use caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet.
- Stay hydrated.
- Adhere to blood pressure management strategies.
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