Resco
Generic Name
Risperidone
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| resco 2 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Risperidone is an atypical antipsychotic medication used to treat schizophrenia, bipolar disorder, and irritability associated with autistic disorder. It helps to restore the balance of certain natural substances in the brain (neurotransmitters).
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 2 mg once daily, target dose 4-8 mg/day. Bipolar mania: Initially 2-3 mg once daily. Autistic irritability: Based on weight, often starting at 0.5 mg/day.
Elderly
Start with 0.5 mg twice daily. Increase dose slowly if needed.
Renal_impairment
Start with 0.5 mg twice daily. Max 1.5 mg twice daily. Adjust with caution.
How to Take
Take orally, with or without food, usually once or twice a day as directed by your doctor. Swallow the tablet whole with water.
Mechanism of Action
Risperidone works by blocking dopamine D2 receptors and serotonin 5-HT2A receptors in the brain. This action helps to reduce the positive and negative symptoms of schizophrenia and stabilize mood in bipolar disorder.
Pharmacokinetics
Onset
Initial effects may be seen within days, but full therapeutic effects typically take several weeks.
Excretion
Approximately 70% of the dose is excreted in the urine and 14% in the feces; primarily as metabolites.
Half life
Risperidone: approximately 3 hours; 9-hydroxyrisperidone (active metabolite): approximately 24 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations of risperidone are reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 to 9-hydroxyrisperidone (active and equipotent to risperidone). A smaller extent by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to risperidone or any component of the formulation
- Severe central nervous system (CNS) depression
- Comatose states
Drug Interactions
CNS Depressants
Additive CNS depressant effects.
Antihypertensives
May potentiate orthostatic hypotension.
Dopamine Agonists
Antagonistic effects, may reduce efficacy of dopamine agonists.
CYP3A4 Inducers (e.g., Carbamazepine, Rifampin)
Can significantly decrease plasma concentrations of risperidone and its active metabolite.
CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine)
Can increase plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Management is supportive, including maintaining an open airway, oxygenation, ventilation, and monitoring of cardiovascular function.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted into breast milk; caution advised or consider discontinuing nursing.
Side Effects
Contraindications
- Hypersensitivity to risperidone or any component of the formulation
- Severe central nervous system (CNS) depression
- Comatose states
Drug Interactions
CNS Depressants
Additive CNS depressant effects.
Antihypertensives
May potentiate orthostatic hypotension.
Dopamine Agonists
Antagonistic effects, may reduce efficacy of dopamine agonists.
CYP3A4 Inducers (e.g., Carbamazepine, Rifampin)
Can significantly decrease plasma concentrations of risperidone and its active metabolite.
CYP2D6 Inhibitors (e.g., Fluoxetine, Paroxetine)
Can increase plasma concentrations of risperidone and its active metabolite.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, sedation, tachycardia, hypotension, and extrapyramidal symptoms. Management is supportive, including maintaining an open airway, oxygenation, ventilation, and monitoring of cardiovascular function.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted into breast milk; caution advised or consider discontinuing nursing.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
FDA approved, DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Risperidone has undergone extensive clinical trials supporting its efficacy and safety for approved indications, including studies on long-term use and specific patient populations.
Lab Monitoring
- Fasting blood glucose (at baseline and periodically)
- Lipid panel (at baseline and periodically)
- Prolactin levels (if symptomatic)
- Complete Blood Count (CBC)
Doctor Notes
- Monitor patients for extrapyramidal symptoms, particularly at higher doses.
- Be vigilant for signs of Neuroleptic Malignant Syndrome (NMS).
- Regularly assess metabolic parameters (weight, glucose, lipids).
- Counsel patients on adherence, potential side effects, and the importance of not discontinuing abruptly.
- Consider lower doses in elderly or renally/hepatically impaired patients.
Patient Guidelines
- Take this medication regularly as prescribed, even if you feel well.
- Do not stop taking this medicine abruptly without consulting your doctor, as it can lead to withdrawal symptoms.
- Avoid alcohol consumption while taking this medication.
- Report any unusual side effects, especially uncontrollable muscle movements, to your doctor immediately.
- Be aware of potential weight gain and monitor your diet and exercise.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause drowsiness, dizziness, or blurred vision. Do not drive or operate heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet to manage potential weight gain.
- Engage in regular physical activity.
- Practice stress-reduction techniques.
- Ensure adequate sleep.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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