Resitone
Generic Name
Piracetam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| resitone 20 mg tablet | ৳ 6.02 | ৳ 60.20 |
| resitone 40 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Resitone (Piracetam) is a nootropic drug primarily used to improve cognitive functions, especially in conditions involving memory loss, attention deficits, and impaired mental performance. It is also used in cortical myoclonus and vertigo.
Uses & Indications
Dosage
Adults
For cognitive disorders: 2.4-4.8 g/day in 2-3 divided doses. For cortical myoclonus: Initially 7.2 g/day, gradually increasing by 4.8 g every 3-4 days up to a maximum of 24 g/day in 2-3 divided doses.
Elderly
Dosage adjustment is necessary based on renal function. Use with caution.
Renal_impairment
Reduce dose based on creatinine clearance: CrCl 50-79 ml/min: 2/3 of usual dose in 2-3 divided doses; CrCl 30-49 ml/min: 1/3 of usual dose in 2 divided doses; CrCl <30 ml/min: Not recommended. Not for severe renal failure.
How to Take
Tablets can be taken with or without food. Swallow whole with water. Do not chew or crush.
Mechanism of Action
Piracetam enhances cholinergic and glutamatergic neurotransmission, improves neuronal membrane fluidity, facilitates cerebral blood flow, and protects neurons from hypoxic damage. It influences neuronal and vascular functions without being a direct stimulant or sedative.
Pharmacokinetics
Onset
Effects may gradually become apparent over several weeks of consistent treatment.
Excretion
Primarily excreted unchanged in urine, with 80-100% of the dose eliminated within 24-48 hours.
Half life
Approximately 4-5 hours in plasma and 6-8 hours in cerebrospinal fluid.
Absorption
Rapid and almost complete absorption from the gastrointestinal tract. Peak plasma levels are reached within 0.5-1 hour.
Metabolism
Piracetam is not metabolized in the human body.
Side Effects
Contraindications
- Hypersensitivity to Piracetam or other pyrrolidone derivatives or to any excipients.
- Severe renal impairment (creatinine clearance < 20 ml/min).
- Cerebral hemorrhage.
- Huntington's chorea.
Drug Interactions
Thyroid hormones
Concurrent use with thyroid extracts may cause confusion, irritability, and sleep disturbances.
CNS depressants/stimulants
No significant interactions, but caution is advised with other CNS active agents.
Anticoagulants (e.g., Warfarin)
May potentiate the effects of anticoagulants and prolong prothrombin time.
Storage
Store in a cool and dry place, below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, symptomatic and supportive treatment should be administered. There is no specific antidote.
Pregnancy & Lactation
Not recommended during pregnancy or lactation unless clearly indicated and potential benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Piracetam has been studied extensively, with clinical trials exploring its efficacy in conditions like cognitive impairment, dementia, myoclonus, and vertigo. While some studies show benefit, the evidence for its broad use in cognitive enhancement is mixed.
Lab Monitoring
- Regular monitoring of renal function, especially in elderly patients or those with pre-existing renal impairment.
- In patients with cortical myoclonus, monitor electrophysiological parameters.
Doctor Notes
- Advise patients on the importance of gradual withdrawal to avoid potential rebound effects, especially in myoclonus.
- Monitor renal function, particularly in elderly patients, and adjust dosage accordingly.
- Consider potential interactions with anticoagulants and thyroid hormones.
Patient Guidelines
- Do not stop taking the medicine suddenly without consulting your doctor, as this may lead to withdrawal symptoms or worsening of the condition.
- Inform your doctor about all other medicines, including over-the-counter drugs and herbal supplements, you are taking.
- Report any unusual side effects or worsening of symptoms immediately to your doctor.
- Avoid activities requiring mental alertness until you know how the medicine affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Piracetam may cause drowsiness, dizziness, or nervousness in some individuals, which could impair the ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Regular physical activity can support cognitive health.
- Avoid excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.