Resolve
Generic Name
Ketoconazole 2% Shampoo
Manufacturer
Ego Pharmaceuticals
Country
Australia
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| resolve 2 shampoo | ৳ 250.00 | N/A |
Description
Overview of the medicine
Resolve 2% Shampoo contains ketoconazole, an antifungal agent, used to treat fungal infections of the scalp, such as dandruff, seborrheic dermatitis, and tinea versicolor.
Uses & Indications
Dosage
Adults
For dandruff and seborrhoeic dermatitis: Use twice weekly for 2-4 weeks. For prophylaxis: Once every 1-2 weeks. For pityriasis versicolor: Once daily for 5 days.
Elderly
No specific dosage adjustment required for the elderly. Use as per adult dosage.
Renal_impairment
No specific dosage adjustment required as systemic absorption is minimal.
How to Take
Wet hair thoroughly. Apply a small amount of shampoo to the scalp and affected areas. Lather well and leave on for 3-5 minutes before rinsing thoroughly. Avoid contact with eyes.
Mechanism of Action
Ketoconazole inhibits the synthesis of ergosterol, a vital component of fungal cell membranes, leading to increased permeability and leakage of cellular contents, ultimately resulting in fungal cell death.
Pharmacokinetics
Onset
Relief of symptoms typically within 2-4 weeks of regular use.
Excretion
Minimally excreted systemically; primarily removed with rinsing.
Half life
Systemic half-life is irrelevant due to minimal absorption. Local action persists with regular application.
Absorption
Minimal systemic absorption through the skin after topical application. Primarily acts locally on the scalp.
Metabolism
Minimally metabolized locally; systemic metabolism for absorbed drug (negligible) is hepatic.
Side Effects
Contraindications
- Hypersensitivity to ketoconazole or any of the excipients.
- Open wounds or irritated skin on the scalp.
Drug Interactions
Corticosteroids (topical)
If corticosteroids are being used topically, they should be gradually withdrawn over 2-3 weeks while using ketoconazole shampoo to prevent rebound effects.
Storage
Store below 25°C. Do not freeze. Keep out of direct sunlight.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to minimal absorption. Excessive application may cause local irritation. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Use during pregnancy and lactation is generally considered safe due to minimal systemic absorption. However, consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to ketoconazole or any of the excipients.
- Open wounds or irritated skin on the scalp.
Drug Interactions
Corticosteroids (topical)
If corticosteroids are being used topically, they should be gradually withdrawn over 2-3 weeks while using ketoconazole shampoo to prevent rebound effects.
Storage
Store below 25°C. Do not freeze. Keep out of direct sunlight.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to minimal absorption. Excessive application may cause local irritation. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Use during pregnancy and lactation is generally considered safe due to minimal systemic absorption. However, consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by health authorities in many countries
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of ketoconazole shampoo for its approved indications.
Lab Monitoring
- No specific lab monitoring is required for topical ketoconazole shampoo.
Doctor Notes
- Advise patients on proper application technique and duration.
- Emphasize completion of the full treatment course even if symptoms improve.
- Counsel on potential mild local side effects and when to seek medical advice.
Patient Guidelines
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use on broken or irritated skin.
- If irritation persists, discontinue use and consult a doctor.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. Do not apply extra shampoo to make up for a missed dose. Continue with the regular schedule.
Driving Precautions
Not applicable, as topical application of shampoo is unlikely to affect driving ability.
Lifestyle Advice
- Maintain good scalp hygiene.
- Avoid sharing personal items like combs or hats.
- Follow treatment duration as prescribed for best results.
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Global Brand Names
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