Resopan
Generic Name
Pantoprazole
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| resopan 10 mg tablet | ৳ 3.43 | ৳ 34.29 |
Description
Overview of the medicine
Resopan (Pantoprazole) is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome, and to prevent NSAID-induced ulcers.
Uses & Indications
Dosage
Adults
Typical dosage for GERD and erosive esophagitis is 40 mg once daily for 4-8 weeks. For Zollinger-Ellison syndrome, dosage may vary and be higher.
Elderly
No dosage adjustment is generally required in elderly patients, but caution is advised in those with severe hepatic impairment.
Renal_impairment
No dosage adjustment is generally required in patients with renal impairment.
How to Take
Take orally, usually once daily, before a meal. Do not crush or chew the tablet; swallow it whole.
Mechanism of Action
Pantoprazole works by irreversibly binding to the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby inhibiting the final step in gastric acid production.
Pharmacokinetics
Onset
Onset of action within 2.5 hours.
Excretion
Primarily excreted renally (approximately 80%) and the remainder in feces.
Half life
Terminal elimination half-life is about 1 hour.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 77%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Warfarin
Increased INR and prothrombin time observed in patients receiving PPIs and warfarin concomitantly.
Clopidogrel
Concomitant use may reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase and prolong serum levels of methotrexate, particularly at high doses.
Drugs dependent on gastric pH for absorption
Reduced absorption of drugs like ketoconazole, atazanavir, nelfinavir due to increased gastric pH.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. Symptoms may include mild gastrointestinal disturbances and drowsiness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. It is excreted in human milk, so caution is advised during breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to pantoprazole or any component of the formulation.
- Hypersensitivity to other substituted benzimidazoles.
Drug Interactions
Warfarin
Increased INR and prothrombin time observed in patients receiving PPIs and warfarin concomitantly.
Clopidogrel
Concomitant use may reduce the antiplatelet effect of clopidogrel.
Methotrexate
May increase and prolong serum levels of methotrexate, particularly at high doses.
Drugs dependent on gastric pH for absorption
Reduced absorption of drugs like ketoconazole, atazanavir, nelfinavir due to increased gastric pH.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. Symptoms may include mild gastrointestinal disturbances and drowsiness. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. It is excreted in human milk, so caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent, generic versions available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of pantoprazole in treating various acid-related disorders, including GERD, erosive esophagitis, and peptic ulcers.
Lab Monitoring
- Magnesium levels (for patients on long-term therapy, especially with diuretics)
- Liver function tests (for patients with hepatic impairment or long-term use)
- Vitamin B12 levels (for patients on long-term therapy)
Doctor Notes
- Educate patients on proper administration and potential long-term risks.
- Monitor magnesium levels in patients on prolonged therapy, especially with diuretics.
- Consider lowest effective dose and shortest duration for all indications.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Do not crush, chew, or break the tablet; swallow it whole.
- If you experience severe or persistent side effects, contact your doctor immediately.
- Inform your doctor about all other medications and supplements you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Resopan is generally safe for driving and operating machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid trigger foods such as spicy foods, fatty foods, caffeine, and alcohol.
- Eat smaller, more frequent meals.
- Elevate the head of your bed to reduce reflux symptoms.
- Maintain a healthy weight.
- Avoid smoking.
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