Reumacid
Generic Name
Diclofenac Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reumacid 100 mg suppository | ৳ 9.00 | N/A |
Description
Overview of the medicine
Reumacid 100 mg Suppository contains Diclofenac Sodium, a non-steroidal anti-inflammatory drug (NSAID) used for pain and inflammation relief. It provides rapid and effective relief from various types of pain, including musculoskeletal pain, osteoarthritis, and menstrual pain.
Uses & Indications
Dosage
Adults
Usually 50-100 mg daily, administered as a single dose or in two divided doses. For acute conditions, up to 150 mg daily in divided doses may be given initially. The suppository is typically inserted into the rectum.
Elderly
Lower doses may be required, and caution is advised due to increased risk of side effects.
Renal_impairment
Use with caution; lower doses may be necessary. Avoid in severe renal impairment.
How to Take
The suppository should be unwrapped and inserted gently into the rectum. It is typically administered once or twice daily, preferably at bedtime for evening dose or as directed by the physician. Wash hands before and after administration.
Mechanism of Action
Diclofenac Sodium inhibits cyclo-oxygenase (COX-1 and COX-2) enzymes, leading to a reduction in prostaglandin synthesis. Prostaglandins are key mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually within 30 minutes to 1 hour.
Excretion
Primarily via urine (approximately 60%) and bile/faeces (approximately 35%) as metabolites.
Half life
Approximately 1-2 hours.
Absorption
Rapidly absorbed from the rectum, reaching peak plasma concentrations within 1-3 hours.
Metabolism
Extensively metabolized in the liver by hydroxylation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- Active gastrointestinal bleeding or peptic ulcer.
- Severe heart failure (NYHA Class IV).
- Severe renal or hepatic impairment.
- Third trimester of pregnancy.
- Proctitis or history of rectal bleeding.
Drug Interactions
Lithium, Methotrexate
Increased plasma levels of lithium and methotrexate, leading to toxicity.
Diuretics, ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs, Corticosteroids
Increased risk of gastrointestinal side effects.
Warfarin, other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, dizziness, tinnitus, headache, and rarely, acute renal failure or liver damage. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Diclofenac should be avoided during the third trimester of pregnancy due to potential risks to the fetus, including premature closure of the ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and under strict medical supervision, as it may be excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to diclofenac, aspirin, or other NSAIDs.
- Active gastrointestinal bleeding or peptic ulcer.
- Severe heart failure (NYHA Class IV).
- Severe renal or hepatic impairment.
- Third trimester of pregnancy.
- Proctitis or history of rectal bleeding.
Drug Interactions
Lithium, Methotrexate
Increased plasma levels of lithium and methotrexate, leading to toxicity.
Diuretics, ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs, Corticosteroids
Increased risk of gastrointestinal side effects.
Warfarin, other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, dizziness, tinnitus, headache, and rarely, acute renal failure or liver damage. Treatment is symptomatic and supportive; there is no specific antidote.
Pregnancy & Lactation
Diclofenac should be avoided during the third trimester of pregnancy due to potential risks to the fetus, including premature closure of the ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and under strict medical supervision, as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various pain and inflammatory conditions.
Lab Monitoring
- Complete Blood Count (CBC): Monitor for signs of bleeding or anemia, especially with long-term use.
- Liver function tests (LFTs): Periodically, especially in patients with pre-existing liver conditions or prolonged therapy.
- Renal function tests (e.g., creatinine, BUN): Periodically, particularly in elderly patients or those with impaired renal function.
Doctor Notes
- Advise patients about potential GI and CV risks, especially in elderly patients or those with pre-existing conditions.
- Monitor renal and hepatic function during long-term therapy.
Patient Guidelines
- Use the suppository rectally as directed by your doctor.
- Do not chew or swallow the suppository.
- Report any signs of stomach pain, black stools, or unusual bleeding to your doctor immediately.
- Avoid alcohol while using this medicine.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Diclofenac may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Regular exercise, if appropriate for your condition.
- Avoid smoking, as it can worsen gastrointestinal issues.
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