Reumazin
Generic Name
Naproxen
Manufacturer
Healthcare Pharmaceuticals
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| reumazin 500 mg tablet | ৳ 5.20 | ৳ 52.00 |
Description
Overview of the medicine
Naproxen is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250-500 mg twice daily, or 500 mg once daily. Maximum daily dose generally not to exceed 1250 mg.
Elderly
Lower doses may be required, closely monitor for adverse effects due to increased risk of side effects in this population.
Renal_impairment
Reduced dosage recommended; monitor renal function closely. Avoid in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief typically begins within 1 hour.
Excretion
Mainly excreted in the urine (approximately 95%) as metabolites and unchanged drug.
Half life
Approximately 12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal (GI) tract after oral administration. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Primarily metabolized in the liver via demethylation and subsequent conjugation with glucuronic acid.
Side Effects
Contraindications
- Known hypersensitivity to naproxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. More severe symptoms can include acute renal failure, respiratory depression, and coma. Management: Symptomatic and supportive care, gastric lavage, activated charcoal, and monitoring of vital signs.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if potential benefits outweigh potential risks. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to naproxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Third trimester of pregnancy
- Severe renal or hepatic impairment
- Coronary artery bypass graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects; increased risk of renal impairment.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. More severe symptoms can include acute renal failure, respiratory depression, and coma. Management: Symptomatic and supportive care, gastric lavage, activated charcoal, and monitoring of vital signs.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if potential benefits outweigh potential risks. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the manufacturer.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety profile of naproxen for its approved indications, demonstrating its effectiveness in pain and inflammation management.
Lab Monitoring
- Complete blood count (CBC) periodically for long-term use
- Liver function tests (LFTs) periodically
- Renal function tests (RFTs) periodically, especially in elderly or patients with pre-existing renal impairment
- Blood pressure monitoring
Doctor Notes
- Advise patients to take with food to minimize GI upset.
- Educate on symptoms of GI bleeding and cardiovascular risks.
- Consider lowest effective dose for shortest duration, especially in elderly or patients with risk factors.
- Monitor renal function, blood pressure, and CBC in patients on long-term therapy.
Patient Guidelines
- Do not exceed the prescribed dose or duration of treatment.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, severe stomach pain) immediately to your doctor.
- Avoid alcohol consumption while taking this medication.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Naproxen may cause dizziness, drowsiness, or visual disturbances in some individuals. Exercise caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking, as it can worsen gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.