Revoc-DS
Generic Name
Cefixime 250 mg/5 ml Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| revoc ds 250 mg suspension | ৳ 120.37 | N/A |
Description
Overview of the medicine
Revoc-DS 250 mg Suspension is an oral antibiotic used to treat various bacterial infections. It contains Cefixime, a third-generation cephalosporin, effective against a wide range of gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
Adults may take 400 mg daily. For suspension, dosage is usually based on weight for children.
Elderly
No dosage adjustment needed unless severe renal impairment.
Renal_impairment
Dosage adjustment required for creatinine clearance < 60 mL/min. For CrCl 21-60 mL/min: 75% of standard dose. For CrCl < 20 mL/min: 50% of standard dose.
How to Take
Shake the bottle well before each use. Can be taken with or without food. Complete the full course of medication as prescribed, even if symptoms improve.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Clinical improvement usually seen within 24-48 hours.
Excretion
Primarily excreted unchanged in urine via glomerular filtration and tubular secretion. A small portion is excreted via bile.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% absorbed orally. Absorption is not significantly altered by food.
Metabolism
Not extensively metabolized in the body.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of severe allergic reactions to penicillin (cross-reactivity is possible)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding. Close monitoring of coagulation parameters is recommended.
Probenecid
May increase cefixime blood levels by decreasing renal tubular secretion.
Oral contraceptives
May reduce the effectiveness of oral contraceptives, advise additional contraceptive methods.
Storage
Store dry powder below 30°C, protected from light and moisture. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-14 days (check specific product leaflet).
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in low concentrations in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or other cephalosporins
- History of severe allergic reactions to penicillin (cross-reactivity is possible)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding. Close monitoring of coagulation parameters is recommended.
Probenecid
May increase cefixime blood levels by decreasing renal tubular secretion.
Oral contraceptives
May reduce the effectiveness of oral contraceptives, advise additional contraceptive methods.
Storage
Store dry powder below 30°C, protected from light and moisture. Reconstituted suspension should be stored in a refrigerator (2-8°C) and discarded after 7-14 days (check specific product leaflet).
Overdose
Gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in low concentrations in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted), 7-14 days (reconstituted, refrigerated)
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of cefixime in various bacterial infections, demonstrating its broad-spectrum activity and favorable tolerability profile.
Lab Monitoring
- Renal function tests (for prolonged therapy or renal impairment)
- Complete blood count (CBC) (for prolonged therapy)
- Prothrombin time (PT)/INR (if co-administered with anticoagulants)
Doctor Notes
- Counsel patients on importance of completing the full course.
- Monitor for signs of allergic reactions, especially in patients with penicillin allergy history.
- Advise on proper reconstitution and storage for suspensions.
Patient Guidelines
- Do not stop taking the medicine early, even if you feel better.
- Inform your doctor if you experience severe diarrhea or allergic reactions.
- Keep out of reach of children.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Stay hydrated.
- Maintain good hygiene to prevent further infections.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.