Rexilo
Generic Name
Ropinirole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| rexilo 120 mg tablet | ৳ 250.00 | ৳ 2,500.00 |
Description
Overview of the medicine
Rexilo is a brand of Ropinirole, a non-ergoline dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome (RLS). It works by stimulating dopamine receptors in the brain.
Uses & Indications
Dosage
Adults
Parkinson's Disease: Initial 0.25 mg three times daily, gradually titrated up weekly based on response and tolerability. RLS: Initial 0.25 mg once daily, 1-3 hours before bedtime, gradually titrated up every 2-7 days.
Elderly
Start with lower doses and titrate carefully, especially in patients with impaired renal function, due to decreased clearance.
Renal_impairment
For mild-to-moderate renal impairment, no dosage adjustment is generally needed. For severe renal impairment (CrCl <30 mL/min) requiring hemodialysis, consider a dosage reduction.
How to Take
Take Rexilo tablets orally with or without food. For RLS, take 1-3 hours before bedtime. Extended-release tablets should be swallowed whole; do not crush, chew, or split them.
Mechanism of Action
Ropinirole is a non-ergoline dopamine D2/D3 receptor agonist. It is believed to work by stimulating dopamine receptors in the brain, thereby mimicking the effects of dopamine, which is deficient in Parkinson's disease.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Primarily excreted via urine (approx. 60% as metabolites, <10% as unchanged drug).
Half life
Elimination half-life is approximately 6 hours (immediate-release) to 6-10 hours (extended-release).
Absorption
Well absorbed after oral administration, bioavailability approximately 55%.
Metabolism
Extensively metabolized by CYP1A2 to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ropinirole or any component of the formulation.
- Severe hepatic impairment (use with caution as data is limited).
Drug Interactions
Estrogens
May decrease ropinirole clearance.
Fluvoxamine
Potent CYP1A2 inhibitor; increases ropinirole exposure.
Ciprofloxacin
Increases plasma levels of ropinirole by inhibiting CYP1A2.
Dopamine antagonists (e.g., antipsychotics, metoclopramide)
May reduce the efficacy of ropinirole.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, somnolence, hyperhidrosis, dyskinesia, agitation, confusion, hallucinations, and psychotic symptoms. Management is symptomatic and supportive; gastric lavage may be considered. Hemodialysis is unlikely to be effective.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ropinirole is excreted in breast milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for Ropinirole
Clinical Trials
Ropinirole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of Parkinson's disease and RLS, leading to its global approval.
Lab Monitoring
- No specific routine laboratory monitoring tests are required. Clinical monitoring for efficacy and side effects is recommended.
Doctor Notes
- Educate patients thoroughly about the potential for sudden sleep attacks and impulse control disorders and encourage open discussion.
- Monitor for signs of postural hypotension, especially during initiation and dose titration.
- Consider a gradual tapering if discontinuation is necessary to minimize withdrawal symptoms.
Patient Guidelines
- Do not stop taking Rexilo suddenly without consulting your doctor, as this can lead to withdrawal symptoms.
- Be aware that Rexilo may cause drowsiness or sudden sleep attacks, especially at the start of treatment or when the dose is increased.
- Report any new or worsening unusual urges or behaviors (e.g., pathological gambling, increased sexual urges) to your doctor immediately.
Missed Dose Advice
If a dose of Rexilo is missed, take the next dose at the regularly scheduled time. Do not take an extra dose or increase the amount of your next dose to make up for a missed one.
Driving Precautions
Rexilo can cause drowsiness, sudden sleep attacks, and fainting, which may impair your ability to drive or operate machinery. You should not drive or engage in such activities until you are certain that Rexilo does not adversely affect your mental or motor performance.
Lifestyle Advice
- Avoid alcohol, as it can intensify the sedative effects of Rexilo and increase the risk of dizziness and drowsiness.
- Maintain a regular sleep schedule to help manage potential sleep disturbances.
- Avoid activities requiring mental alertness (e.g., driving, operating heavy machinery) until you know how Rexilo affects you.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.